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Notes:
Volume10, Issue 12 (Suppl) J Proteomics Bioinform, an open access journal
ISSN: 0974-276X
Page 75
conferenceseries.com
World Biomarkers & Pharma Biotech 2017
December 07-09, 2017
December 07-09, 2017 | Madrid, Spain
&
20th International Conference on
PHARMACEUTICAL BIOTECHNOLOGY
9th WORLD BIOMARKERS CONGRESS
JOINT EVENT ON
The fluctuations in homocysteine level caused by various combinations of folic acid cycle genes SNP
alleles as a factor in the course of pregnancy violation
Andrei V Ivanov
University Hospital of Saint-Petersburg State University, Russia
Female reproductive system disorders are the classic example of the multifactorial diseases. One of its violation factors
including habitual miscarriage and pre-eclampsia is of the pathological alleles of single nucleotide polymorphisms (SNP)
of the folic acid cycle genes presence in the genome. The realizing mechanism for this genetic predisposition is homocysteine
level increasing in the blood named hyperhomocysteinemia. However, the lack of direct correlation between the genotype
of the four most clinically significant SNPs and the blood homocysteine level detected is in some contradiction with the
literature data. This study presenting an attempt to find the relationship between the genotype for the four SNPs of the three
folate cycle genes - C677T and A1298C of the MTHFR gene, A2756G of the MTR gene and the A66G of the MTRR gene
and the homocysteine level in the blood of women with impaired pregnancy. In total there were 131 patients: European
population, reproductive age and residents of the North-West region of Russia. As a result no direct correlation was found
between homocysteine level and folic acid cycle genotype in patients and control group. But it was found a statistically
significant interlation between the presence of pathological alleles of the studied SNP and the mean square deviation (σ) of the
homocysteine level fluctuations over time. For the polymorphism C677T of the MTHFR gene σ of the homocysteine blood
level fluctuation is increased up to four times in women with a homozygous pathological state TT compared with the normal
homozygotes CC. The clinical importance of monitoring the homocysteine blood level has been shown especially for women
with folate cycle genes pathological alleles presence that would help this recognition.
Recent Publications:
1. Uvarova M A, Ivanov A V, Dedul A G, Sheveleva T S and Komlichenko E V (2015) The effect of single nucleotide
genetic polymorphisms of folic acid cycle on the female reproductive system disorders. Gynecological Endocrinology.
31 (1): 34-38.
2. Ivanov A V, Dedul A G, Fedotov Y N and Komlichenko E V (2016) Toward optimal set of single nucleotide
polymorphism investigation before IVF. Gynecological Endocrinology. 32 (2): 11-18.
3. Uvarova M A, Ivanov A V (2016) Three folic acid cycle genes single nucleotide polymorphisms as hereditary factors
for female reproductive system disorders development. Terra Medica. 4 (86): 22-28.
Biography
Andrei V Ivanov is the Head of Department of Human Genetics. He has a PhD in Cell Biology and specialization in Clinical Laboratory Diagnostics. One of his
most productive researches is the influence of genetic part of multifactorial diseases such as female reproductive system disorders, irritable bowel syndrome, and
metabolic syndrome. His interests are metabolomics (especially steroid profiling), cell therapy of diabetic foot syndrome and biobanking. He considers his main task
to be the introduction of results of the biological research into broad medical practice.
Andrei V Ivanov, J Proteomics Bioinform 2017, 10:12(Suppl)
DOI: 10.4172/0974-276X-C1-110