vascular-dementia-2018-scientifictracks-abstracts

16 / 16

Page 50
Notes:
conferenceseries.com
10th International Conference on
February 22-23, 2018 | Paris, France
Vascular Dementia
Volume 8 Journal of Alzheimers Disease & Parkinsonism
ISSN: 2161-0460 Vascular Dementia 2018
February 22-23, 2018
P Giannakopoulos, J Alzheimers Dis Parkinsonism 2018, Volume 8
DOI: 10.4172/2161-0460-C1-036
Multimodal prediction of subtle cognitive decline in elderly controls: An update
Introduction & Aim: The presence of apolipoprotein E4 (APOE*E4) is the strongest currently known genetic risk factor for
Alzheimer’s disease and is associated with brain gray matter loss, notably in areas involved in Alzheimer’s disease pathology.
Our objective was to assess the effect of APOE*E4 on brain structures in healthy elderly controls who subsequently developed
subtle cognitive decline.
Materials & Method: This prospective study included 382 community dwelling elderly controls. At baseline, participants
underwent MR imaging at 3T, extensive neuropsychological testing and genotyping. After neuropsychological follow-up at
18 months, participants were classified into cognitively stable controls and cognitively deteriorating controls. Data analysis
included whole-brain voxel-based morphometry and ROI analysis of GM.
Results: APOE*E4 related GM loss at baseline was found only in the cognitively deteriorating controls in the posterior
cingulate cortex. There was no APOE*E4-related effect in the hippocampus, mesial temporal lobe, or brain areas not involved
in Alzheimer disease pathology. Controls in the cognitively deteriorating group had slightly lower GM concentration in the
hippocampus at baseline. Higher GM densities in the hippocampus, middle temporal lobe, and amygdala were associated with
a decreased risk for cognitively deteriorating group status at follow-up.
Conclusions: APOE*E4 related GM loss in the posterior cingulate cortex (an area involved in Alzheimer disease pathology)
was found only in those elderly controls who subsequently developed subtle cognitive decline but not in cognitively stable
controls. This finding might explain the partially conflicting results of previous studies that typically did not include detailed
neuropsychological assessment and follow-up. Most important, APOE*E4 status had no impact on GMdensity in areas affected
early by neurofibrillary tangle formation such as the hippocampus and mesial temporal lobe.
Biography
P Giannakopoulos has obtained his MD at University of Athens in 1989 before completing a full training on Psychiatry and Psychotherapy in London at Maudsley Hospital
and Geneva as well as Post-doctorate training in Paris at La Pitié-Sâlpetrière Hospital, Federation of Neurology. In 1998, he has been appointed as anAssociate Professor
and Medical Head of the Division of Geriatric Psychiatry of the University Hospitals of Geneva. Later on he obtained the position of full tenured Professor of Psychiatry at
University of Geneva. From 2003 to 2011, he also assumed a parallel position of Full Professor of Old Age Psychiatry at University of Lausanne in order to promote the
academic careers of junior staff locally. He has been the Chairman of the Department of Mental Health and Psychiatry in Geneva for 10 years (2005-2015); Vice Dean of
the Faculty of Medicine at University of Geneva and; In-charge of postgraduate and continuous education (2003-2011). From December 1st 2015, he is the Medical Head
of the Forensic Psychiatry Development in Geneva County. He has published more than 220 peer reviewed articles in the field of neurobiology of aging with particular
focus on predictive biomarkers of cognitive decline.
P Giannakopoulos
University of Geneva, Switzerland