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conferenceseries.com
10th International Conference on
February 22-23, 2018 | Paris, France
Vascular Dementia
Volume 8 Journal of Alzheimers Disease & Parkinsonism
ISSN: 2161-0460 Vascular Dementia 2018
February 22-23, 2018
Serum levels of high molecular weight adiponectin and leptin in elderly patients with dementia
Marwa Ahmed Mohamed Saad
Alexandria University, Egypt
Dementia is a progressive impairment of cognitive function sufficient to cause functional decline. It may affect up to 28 million
individuals worldwide; 30% of those older than 85 years. Adiponectin is a cytokine released by the adipose tissue, and presents in
the cerebrospinal fluid of human. It has important functions in the central nervous system. Leptin is another cytokine was implicated
in cognitive decline and dementia processes. We aimed in the present study to determine the serum levels of adiponectin and leptin
in elderly patient with dementia. 60 subjects aged 65 years and older were involved, divided into two groups; group-1: 40 demented
patients and group-2: 20 age and sex matched healthy subjects as a control group. Participants with dyslipidemia, hypertension,
diabetes mellitus, chronic liver diseases, chronic kidney diseases, thyroid disorders, or morbid obesity were excluded from the study.
All participants were subjected to MMSE and MOCA tests, serum adiponectin and leptin were measured. Serum adiponectin was
higher, while leptin levels were lower in demented patients. A significant negative correlation between serum levels of adiponectin
and both MMSE and MOCA scores, while a high positive correlation was noted between serum levels of leptin and both MMSE and
MOCA scores. We concluded that serum adiponectin and leptin were strongly associated with dementia in elderly patients, which
may help in understanding of its pathogenesis and emergence of new drugs for better outcome of this devastated disease.
Biography
Marwa Ahmed Mohamed Saad has completed her Master’s degree in Internal Medicine and Doctorate degree in Internal and Geriatric Medicine at Alexandria
University, Egypt. She is currently working as an Assistant Professor of Geriatric Medicine, Consultant of Internal and Geriatric Medicine and Fellow of Egyptian
Society of Geriatrics and Gerontology.
Marwa Ahmed Mohamed Saad, J Alzheimers Dis Parkinsonism 2018, Volume 8
DOI: 10.4172/2161-0460-C1-036