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Volume 6 Journal of Infectious Diseases & Therapy Tropical & Bacterial Diseases 2018
December 05-06, 2018
Page 58
Notes:
conferenceseries.com
Annual Conference on
Bacterial, Viral and Infectious Diseases
&
Neglected Tropical Diseases Congress: The Future Challenges
December 05-06, 2018 Dubai, UAE
MicroRNA Differential Expression in Chronic HCV Cases from Jeddah, Saudi Arabia
Mohammed M. Al-Ahmari1, Sherif A. El-Kafrawy2, Mai M. El-Daly 2, Ghazi A. Jamjoom2, Hind B. Fallatah3, Hisham O. Akbar3, Esam I. Azhar1,2
1Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia
Hepatitis C virus (HCV) is one of the major global causes of morbidity and mortality, recent estimates showed that >185 millions
are infected worldwide. Chronic HCV infection is often associated with the development of liver cirrhosis, hepatocellular cancer,
liver failure, and death. Saudi Arabia is the largest country in the Gulf region by population and area. There is large variability in
HCV prevalence reported in different population groups in Saudi Arabia ranging from 0% among blood donors to 34.0% in high risk
groups. MicroRNAs are short, non-coding RNAs that are partially complementary to regulatory regions of target messenger RNAs.
MicroRNA binding suppresses translation of target mRNAs or promotes mRNA degradation. Measurement of serum microRNAs
is reported to be correlated with the expression of these microRNAs in the liver. MicroRNA dysregulation is involved in all stages
of hepatocarcinogenesis, their profiles have the potential to discriminate patients with HCC from those with other liver diseases.
A number of studies have reported miR-21 to be frequently up-regulated in HCC tumors, while serum miR-122 is up-regulated in
patients with HCC. In this study, we have investigated the levels of mir-21 and miR-122 in the serum of HCV related HCC cases
compared to their levels in chronic HCV cases. Our result showed increased expression of both mir-21 and mir-122 in HCV related
HCC cases and in chronic HCV cases with high fibrosis score compared to chronic HCV cases with low fibrosis score.
Mohammed M. Al-Ahmari et al., J Infect Dis Ther 2018, Volume 6
DOI: 10.4172/2332-0877-C7-057