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Volume 6
Journal of Infectious Diseases & Therapy
Tropical & Bacterial Diseases 2018
December 05-06, 2018
Page 54
Notes:
conference
series
.com
Annual Conference on
Bacterial, Viral and Infectious Diseases
&
Neglected Tropical Diseases Congress: The Future Challenges
December 05-06, 2018 Dubai, UAE
Monitoring of opportunistic micro-sporidia in immune-compromised patients in Slovakia
Monika Halanova, Pavol Jarcuska, Zuzana Kalinova, Lenka Cechova and Ingrid Babinska
Pavol Jozef Safarik University, Slovakia
T
he importance of opportunistic pathogens, which are able to be agents of disease only if the natural defence mechanisms are
damaged and function of immune system is decreased, is growing due to an increasing number of patients with HIV infection/
AIDS, as well as other persons with disrupted immune systems due to primary or secondary immunodeficiency. Micro-sporidia are
among the opportunistic pathogens that are occurring with greater frequency or severity in patients with impaired host defenses.
Therefore, the aim of our study was to map the prevalence of
Encephalitozoon intestinalis
and
Enterocytozoon bieneusi
infection in a
group of patients and to compare it with the occurrence of specific antigens in immune-competent people. Detection of spores of both
pathogens in fecal samples was performed by an immunofluorescence test using species-specific monoclonal antibodies. Overall, we
examined 142 people, including 80 men and 62 women. We compared the relative risk of micro-sporidia between groups of immune-
compromised patients and immune-competent persons. The risk of occurrence of micro-sporidia Encephalitozoon intestinalis in the
group of HIV/AIDS patients was 6.6 times higher, in the group of hemodialysis patients 1.6 times and in the group of renal transplant
patients 4 times higher in comparison with the immune-competent persons. The risk of occurrence of micro-sporidia
Enterocytozoon
bieneusi
in the group of HIV/AIDS patients was 10 times higher and in the group of renal transplant patients 6.7 times higher in
comparison with the immune-competent persons. In the group of hemodialysis patients, the risk of occurrence of micro-sporidia
Enterocytozoon bieneusi
was the same as in the group of immune-competent persons.
Biography
Monika Halanova has completed DVM Degree at University of Veterinary Medicine in Kosice in 1995 and PhD in Infectious and Parasitic Diseases in 2000. She was
honored as Associate Professor in Epidemiology at Pavol Jozef Safarik University in Kosice, Faculty of Medicine in 2008. She works with several labs focusing on
the diagnosis of infectious and parasitic diseases and long lasting study stay in Central Laboratory in Abu Dhabi, UAE. Her research takes place at the crossroads
of public health, epidemiology and infectious diseases. She has been part of several research projects as principal investigator or scientific co-worker. She has
published around 367 scientific papers and abstracts.
monika.halanova@upjs.skMonika Halanova et al., J Infect Dis Ther 2018, Volume 6
DOI: 10.4172/2332-0877-C7-057