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Volume 8
Journal of Traditional Medicine & Clinical Naturopathy
Page 29
June 20-21, 2019 Dubai, UAE
Joint Meeting on
&
2
nd
World Congress on Traditional & Complemenatry Medicine
2
nd
International Conference on Herbal & Traditional Medicine
Traditional Med Meet 2019 &
Herbal Traditional 2019
June 20-21, 2019
Watchara Damjuti, J Tradit Med Clin Natur 2019, Volume 8
Hypnotic and anti-anxiety activities of Thai traditional antinausea remedy
Watchara Damjuti
Rajamangala University of Technology Thanyaburi, Thailand
T
hai traditional antinausea remedy is drug registered in the National List of Essential Medicines (NLEM)
for the treatment of blood circulation disorders, dizziness, fatigue and insomnia. Antinausea remedies
have long been used, but their effects and action mechanisms remain poorly understood. This study aimed
to examine the hypnotic with mechanistic study and its anxiolytic capabilities. Healthy adult male Swiss
albino mice were used for the study. Thiopental sodium-induced sleeping time with GABAergic activity was
evaluated. The latent period and sleeping time of aqueous extract groups were recorded and compared to the
control group and pretreated GABA antagonistic blocker group by observing the righting reflex. Aqueous
extracts at doses of 10, 50 and 100 mg/kg significantly augmented the latent time between waking and onset
of sleep. Sleeping times of mice were also prolonged at the same dose with latent phase. In addition, extract at
a dosage of 100 mg/kg pretreated with flumazenil reduced latent time compared to negative control and also
shortened sleeping times (P<0.05). In addition, anti-anxiety was also investigated using evaluated plus maze
test, aqueous extract at 10 mg/kg marginally decreased the time rodents spent in the closed arms, whereas
50 and 100 mg/kg greatly increased the time rodents spent in the open arms of the plus maze (P<0.05). It is
concluded that the aqueous extract has potential as a hypnotic and anti-anxiety effect. Our findings can be
used to ensure that proper precautions and drug correctly used. Further studies are required to determine the
pharmacodynamics of Thai traditional antinausea remedy and analyze its chemical metabolism to discover
drug absorption and elimination.
Biography
Watchara Damjuti has completed his PhD from Chulalongkorn University, Thailand. He is currently working as the Lecturer at Rajamangala
University of Technology Thanyaburi, Thailand.
watchara_d@rmutt.ac.th