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Volume 08
Journal of Novel Physiotherapies
Rehabilitation Medicine 2018
May 18-19, 2018
May 18-19, 2018 Osaka, Japan
7
th
World Congress on
Physical Medicine and Rehabilitation
Comparison between platelet-rich plasma and hyaluronic acid treatments for talar osteochondral
lesions: A network meta-analysis of randomized controlled trials
Wei Li
Taipei Medical University Hospital, Taiwan
Introduction & Purpose:
Both platelet-rich plasma (PRP) and hyaluronic acid (HA) with or without surgical intervention can
enhance healing and improve function in talar OCLs. However, recent studies on OCLs have not thoroughly investigated the
effects among PRP, HA and conventional treatment. The purpose is to synthesize evidence by comparing the effects (pain score
and foot and ankle condition scores) among PRP, HA and conventional treatment strategies for talar OCLs.
Material &Method:
All relevant research articles were included using related terms in the PubMed, EMBASE, Web of Science,
Science Direct and Cochrane library databases from their inception to June 2017. The screening criteria for this systematic
review were as follows: Randomized controlled trials (RCTs) that compared PRP with HA, PRP with control and HA with
control in patients with talar OCLs. The risk of bias in the included studies was assessed using the Cochrane Risk of Bias
Tool. Data were extracted and recorded as weighted mean difference (WMD) and their standard deviations (SDs) with 95%
confidence intervals (CI), consistency H and I-2 for continuous data in the network meta-analysis.
Result:
A total of 1199 references were identified, of which five RCTs were included in the final synthesis. These studies
randomized 197 patients into the PRP, HA and control groups. PRP caused higher reductions in the visual analog scale score
than HA and conventional treatment and the WMDs were 1.109 (95% CI: -1.716, -0.502) and -2.301 (95% CI: -2.825, -1.777).
Moreover, PRP improved the American Orthopedic Foot and Ankle Society score more than the other treatment methods and
the WMDs were 12.448 (95% CI: 7.224, 17.672) and 18.617 (95% CI: 13.536, 13.698).
Conclusion:
PRP reduced pain and improved ankle conditions to a greater extent than HA and conventional treatment.
Therefore, PRP might be recommended for the treatment of talar OCLs. Further investigation is required to guarantee the
safety and efficacy of different surgical treatments.
a4910131@gmail.comJ Nov Physiother 2018, Volume 8
DOI: 10.4172/2165-7025-C2-027