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Regenerative & Precision Medicine 2016
December 1-2, 2016
Volume 7, Issue 3(Suppl) J Tissue Sci Eng
ISSN: 2157-7552 JTSE, an open access journal
conferenceseries .com
December 1-2, 2016 | San Antonio, USA
Global Congress on
Tissue Engineering, Regenerative &
Precision Medicine
Zhao-Jun Liu et al., J Tissue Sci Eng 2016, 7:3(Suppl)
Nanocarrier-directed targeted cell delivery for stem cell therapy
Zhao-Jun Liu, Pirouz Daftarian, Bo Wang, Diego M Castilla, Emre Dikici, Victor L Perez, Sapna Deo, Sylvia Daunert and Omaida C Velazquez
University of Miami, USA
S tem cell-based therapy has emerged as a promising treatment option in regenerative medicine. However, targeted systemic
delivery of therapeutic cells to the dysfunctional tissues remains one formidable challenge. Herein, we present a targeted
nanocarrier-mediated cell delivery method by coating the surface of the cell to be delivered with dendrimer nanocarriers
modified with adhesion molecules. Infused nanocarrier-coated cells reach to destination via recognition and association
with the counterpart adhesion molecules highly or selectively expressed on the activated endothelium in diseased tissues.
Once anchored on the activated endothelium, nanocarriers-coated transporting cells undergo transendothelial migration,
extravasation and homing to the targeted tissues to execute their therapeutic role. We now demonstrate feasibility, efficacy and
safety of our targeted nanocarrier for delivery of bone marrow cells (BMC) to cutaneous wound tissues and grafted corneas
and its advantages over conventional BMC transplantation in mouse models for wound healing and neovascularization. This
versatile platform is suited for targeted systemic delivery of virtually any type of therapeutic cell.
Biography
Zhao-Jun Liu is an Associate Professor at University of Miami, Miller School of Medicine. His research interests span both vascular biology and cancer biology. He
has published more than 60 research papers, review articles and book chapters.