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Regenerative & Precision Medicine 2016
December 1-2, 2016
Volume 7, Issue 3(Suppl) J Tissue Sci Eng
ISSN: 2157-7552 JTSE, an open access journal
conferenceseries .com
December 1-2, 2016 | San Antonio, USA
Global Congress on
Tissue Engineering, Regenerative &
Precision Medicine
Kobra Tahermanesh et al., J Tissue Sci Eng 2016, 7:3(Suppl)
Biocompatibility and biodegradation response of synthesized Mg-Zn-Ca alloys on viability of
adipose derived mesenchymal stem cells
Kobra Tahermanesh and Abbas Fazel Anvari-Yazdi
Iran University of Medical Sciences, Iran
Materials and Biomaterials Research Center, Iran
Magnesium (Mg) based alloys have been extensively considered for their use as biodegradable implant materials. However,
controlling their corrosion rate in the physiological environment of the human body is still a significant challenge. One of the
most effective approaches to address this challenge is to carefully select alloying compositions with enhanced corrosion resistance
when designing theMg alloys. In this study ternaryMg-2 wt.%Zn-xCa (x=1, 2 and 3 wt.%) alloys as biodegradablemagnesiumalloys
were studied.The microstructures of the alloys were examined with optical microscopy, Scanning ElectronMicroscopy (SEM), X-ray
diffraction (XRD) examinations as well as potentiodynamic polarization (PDP). Biocompatibility of mentioned alloys performed
with indirect MTT viability test according to ISO 10993-5:2009 standard. The microstructural examinations demonstrated that by
addition of 1, 2 and 3 wt.% Ca, the grain size reduced from 807 μm for Mg-2Zn to 86, 36 and 17 μm, respectively. Mg-2Zn has the
least corrosion potential and current density among all groups (Ecorr=-1.56 and i corr=152 μA cm2) due to well solubility of Zn; however,
among Mg alloys which contain Ca content, the best corrosion properties related to Mg-2Zn-1Ca alloy (Ecorr=-1.57 and i corr=195 μA/
cm2). The viability results indicate that Mg alloys extract have no significant toxicity effect on adipose derived mesenchymal stem
cells (ASCs) viability; however the viability increased in Mg-2Zn-1Ca group. Also, direct ASCs culturing on the surface of Mg alloys
represented good attachment and proliferation.
Biography
Kobra Tahermanesh has completed her Medical degree from Shiraz University of Medical Sciences and graduated first Fellowship of Minimally Invasive Gynecology
Surgery from Tehran University of Medical Sciences, Iran. She is an Assistant Professor of Iran University of Medical Sciences and Director of a research team
focusing on bio-instruments and biodegradable implants for tissue engineering. She has a knowledge-based company in field of biomedical and tissue engineering.
She is interested to work on interdisciplinary basic sciences and bio-engineering researches and do her best to connect the medical and engineering scientists to
each other.