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Volume 4, Issue 5 (Suppl)
J Pharmacovigil 2016
ISSN:2329-6887 JP, an open access journal
Pharmacovigilance Congress 2016
September 28-30, 2016
September 28-30, 2016 Toronto, Canada
6
th
Pharmacovigilance Congress
Tariel V Ghochikyan, J Pharmacovigil 2016, 4:5 (Suppl)
http://dx.doi.org/10.4172/2329-6887.C1.024New syntheses in the field of
τ
-lactones and biological studies of the obtained compounds
Tariel V Ghochikyan
Yerevan State University, Armenia
A
wide range of biological action and prevalence of lactone-containing compounds in the nature become attractive objects for
research by both specialists in fine organic synthesis and pharmacologists. There are numerous drugs used in medicine that
contain active aglycones derivatives of γ-lactones. The relevance of research in the field of γ-lactones is confirmed by numerous recent
publications. In continuation of our research in this field, we have developed a number of methods for the synthesis of new, earlier
not described in literature lactone-containing compounds that can be of certain practical interest. Below there is a graphical scheme
of our research. Screening of compounds 1,2 revealed that they displayed inhibitory activity in relation to major phosphatases. It
is shown that the inhibitory activity of the main part of studied compounds exceeded similar properties of the known inhibitors
levamisil and L-phenylalanine by 17-80 times. Compounds 3 are of certain interest. Their studies have shown that representatives
of this class have mainly antibacterial properties were used Gram-positive staphylococci (209P, 93) and gram-negative rods (Sh.
Flexner 6858, E coli 0-55), all compounds had moderate anti¬bacterial activity. Screening has revealed antimutagenic properties in a
series of γ-lactones for the first time (compounds 3, 4). The experiments were carried out on
Salmonella tiphimurium
TA-100. It was
established that with these compounds the number of revertants decreased by 55-60% and mutagenicity factor w as 2.58-2.7. The
same compounds exhibited algicidal activity against filamentous green algae Cladophora. The mentioned compounds in 1 mg/ml
concentration destroy cells for 51-60% against 14% of the control preparation monuron. Undoubtedly, compounds 3, 4 can be used
in solution of some ecological problems.
O
R
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R '
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R '"= R4
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5
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N
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2
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3
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- C - CH
3
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2
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1
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4
N
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4
Biography
Tariel V Ghochikyan has completed his Doctor of Sciences degree from Supreme Certifying Commission of the Republic of Armenia (Yerevan State University).
He is Dean of the Department of Pharmacology and Chemistry, YSU. He is Supervisor and Master Researcher of Research Laboratory, “Chemistry of N-,S-,O-
containing heterocyclic compounds”. He has published more than 225 articles, international thesis and patents in the reputed journals. He is the member of the
Council of YSU, member of special soviet unions. He is an Editorial Board Member of
Chemical Journal of Armenia
, and also for the proceedings of YSU Chemical
and Biological Sciences.
tghochikyan@gmail.am