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Volume 4, Issue 5 (Suppl) J Pharmacovigil 2016
ISSN:2329-6887 JP, an open access journal Pharmacovigilance Congress 2016
September 28-30, 2016
September 28-30, 2016 Toronto, Canada
6th Pharmacovigilance Congress
Armen S Galstyan, J Pharmacovigil 2016, 4:5 (Suppl)
Derivatives of 1,2,4-triazoles: Synthesis and study of biological activity
Armen S Galstyan
Yerevan State University, Armenia
One of the most interesting classes of organic compounds such as nitrogen, oxygen, and sulfur-containing heterocycles have a
wide range of practical use. In particular 1,2,4-triazol-ring included in the structures of different biologically active molecules,
are used as drugs with broad spectrum action, e.g. antimicrobial (Fluconazole, Itraconazole), anticancer (Vorozole, Letrozole,
Anastrozole), and some derivatives have antibacterial, antifungal, antitumour, anti-inflammatory, antitubercular, hypoglycemic,
antidepressant, anticonvulsant, antiviral and analgesic activity. This work presents some synthetic possibilities of 3,4-disubstituted-
5-mercapto-1,2,4-triazoles to obtain new potentially biologically active compounds. For functionalization of tria¬zoles, we carried
out the cyanoethylation and (methoxy¬car¬bonyl)ethylation reactions in the reaction conditions. The basic and acid hydrolysis
of the resulted compounds was realized, which led to the corresponding 3-heterylsubstituted propionic acids. Hydrazinolysis of
synthesized esters of hydrazides were obtained. The last are given in 1,3,4-oxadiazoles and pyrazoles according to known methods.
Sulfur-substituted 1,2,4-triazoles derivatives may also be interesting in biological viewpoint. This would enable the biological activities
of free and substituted thiols to be compared. Therefore, 1,2,4-triazoles were alkylated by various aralkyl halides. In order to obtain
the derivatives of thiazolo[2,3-c]-1,2,4-triazoles studied the bromination reaction of 4-allyl and 4-methallyl substituted triazoles.
Preliminarily tests of compounds S-derivatives for antioxidant activity revealed that the latter exerts stabilizing effect on red blood
cell membranes. Screening of some compounds revealed that they exhibit feebly marked antibacterial and anti-yeast activity. But
3-benzyl-1-(2-(5-mercapto-1,3,4-oxadiazol-2-yl)ethyl)-4-phenyl-1H-1,2,4-triazole-5(4H)-thione could inhibit the growth of Gram
positive bacteria.
Biography
Armen S Galstyan has completed his PhD from Supreme Certifying Commission of the Republic of Armenia and Postdoctoral studies from Yerevan State University.
He is Head of Educational Laboratory, Department of Organic Chemistry, YSU, and Research Associate of Research Laboratory, “Chemistry of N-, S-, O-containing
Heterocyclic Compounds”. He has published more than 45 international thesis, patents and articles in the reputed journals.