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Volume 08
Clinical Pharmacology & Biopharmaceutics
ISSN: 2167-065X
Pharmacology 2019
World Heart Congress 2019
August 19-20, 2019
JOINT EVENT
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August 19-20, 2019 Vienna, Austria
&
7
th
World Heart Congress
24
th
World Congress on
Pharmacology
The effects of vitamin D supplementation on ADHD (Attention De cit Hyperactivity Disorder) in 6–13
year-old students: A randomized, doubleblind, placebo-controlled study
Amirmansour Alavi Naeini
a
, Forough Fasihi
a
, Mostafa Najafi
b
, Mohammad Reza Ghazvini
c
and
Akbar Hasanzadeh
d
a,b,d
Isfahan University of Medical Sciences, Iran
c
National Institute of Health Research, Iran
Introduction
: Attention Deficit Hyperactivity Disorder (ADHD) is a common mental disorder in children. Drug
treatment is the most prevalent method used to control it; however, considering the low e cacy and frequent side
e ects of current drugs, more attempts are needed to replace them with safer agents. Several studies have shown the
beneficial role of micronutrients such as vitamin D in development and improving the performance of neuronal
system. This research intended to study the e ects of vitamin D supplementation in 6–13 year-old students with
ADHD.
Methods
: In this double-blind parallel clinical trial, the subjects were selected from among 6–13 year-old students
with ADHD diagnosed by a child psychiatry specialist. Vitamin D3 supplements (1000 IU) or placebo given daily
to 70 subjects for three months. ADHD symptoms were evaluated before and after the intervention using Conners
Parent Questionnaire (CPQ), the Strengths and Di culties Questionnaire Teacher Version (SDQT), the Strengths
and Di culties Questionnaire Parent Version (SDQP) and Continuous performances Test (CPT) scores.
Results
: The mean scores of the CPQ, SDQP and SDQT showed a significant di erence in the two groups after
intervention (p < 0.05). The impulsivity mean scores of the CPT after intervention showed statistical significance (p
=0.002), but the attention (p =0.11) and mean reaction time (p =0.19) mean scores did not.
Conclusions
: VitaminD supplementation not only improves some behavioral problems butmay prevent exacerbation
in some symptoms of the disorder and reduce impulsivity.
Amirmansour Alavi Naeini et al., Clin Pharmacol Biopharm, Volume 08