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Volume 08
Clinical Pharmacology & Biopharmaceutics
ISSN: 2167-065X
Pharmacology 2019
World Heart Congress 2019
August 19-20, 2019
JOINT EVENT
conferenceseries
.com
August 19-20, 2019 Vienna, Austria
&
7
th
World Heart Congress
24
th
World Congress on
Pharmacology
Toxicity test of emodin in ICR mice
Sang Youn Hwang*, Jung Woo Im*, Ki Jeong Jeon*, Seon-Mi Lee*, Cheol Won Choi*, Ja Woong Shim*
and
Kyu Heo*
Pusan National University (PNU), South Korea
Background/Aims
: The application of radiotherapy of hepatocellular carcinoma (HCC) is limited due to
radioresistance in tumor and radiotoxicity in nontumorous liver. Therefore, study for radioresistance mechanism
and improvement of killing effect of irradiation by therapeutic insult such as radiosensitizer etc. Emodin
(1,3,8-trihydroxy-6-methylanthraquinone), a family of plant derived polyphenolhas been proven to have anticancer
properities. We performed
in vivo
study using BALBc/nude mice to prove the effect of emodin as radiosensitizer last
year. Therefore we performed toxicity study of emodin in the view of new drug development.
Methods
: ICR mice was used in this study. Mice were treated with five different manners; none (control), 5mg/
kg, 50mg/kg, 100mg/kg, 250mg/kg of emodin. Emodin was administered only one time and we investigated body
weight, activity, food intake of mice and harvested them within one month. Then we measured organ weight & gross
morphology
Results
: No systemic toxicity of emodin was found in ICR mice (Figure 1, 2), but hematologic toxicity as subtle
anemia and thrombocytopenia was suspcious in 250mg/kg injected group.
Conclusions
: Therefore, our findings may provide that emodin can be developed as new tolerable radiosensitizer in
HCC and may aid in the design of new therapeutic strategies for the radioresistant HCC.
Recent Publications:
1.
Hwang SY, Cho M et al. Effectiveness and complications of combination therapy with interferon alpha and
ribavirin in patients with chronic hepatitis C. Korean J Gastroenterol. 2007 Mar;49(3):166-72.
2.
Hwang SY, Roh YH et al. Extramedullary plasmacytoma of the pancreas diagnosed using endoscopic
ultrasonography-guided fine needle aspiration. Clin Endosc. 2014 Jan;47(1):115-8.
3.
Hwang SY, Lee JH et al. Spontaneous fungal peritonitis: a severe complication in patients with advanced liver
cirrhosis. Eur J Clin Microbiol Infect Dis. 2014 Feb;33(2):259-64.
4.
Hwang SY, Yang KM et al. Emodin attenuates radioresistance induced by hypoxia in HepG2 cells via the
enhancement of PARP1 cleavage and inhibition of JMJD2B. Oncol Rep. 2015 Apr;33(4):1691-8.
5.
Hwang SY, Kim YJ et al. Reduction of oxidative stress attenuates lipoapoptosis exacerbated by hypoxia in
human hepatocytes. Int J Mol Sci. 2015 Feb 3;16(2):3323-34.
6.
Chung GE, Hwang SY, KimYJ et al. Transarterial chemoembolization can be safely performed in patients with
hepatocellular carcinoma invading the main portal vein and may improve the overall survival. Radiology.
2011 Feb;258(2):627-34.
7.
Lee JH, Hwang SY, Yoon JH et al. Simple scoring system predicting genotypic resistance during rescue therapy
for Lamivudine-resistant chronic hepatitis B. J Clin Gastroenterol. 2012 Mar;46(3):243-50.
8.
Chung GE, Hwang SY, KimW et al. Add-on adefovir is superior to a switch to entecavir as rescue therapy for
Lamivudine-resistant chronic hepatitis B. Dig Dis Sci. 2011 Jul;56(7):2130-6.
Sang Youn Hwang et al., Clin Pharmacol Biopharm, Volume 08