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Volume 08
Clinical Pharmacology & Biopharmaceutics
ISSN: 2167-065X
Pharmacology 2019
World Heart Congress 2019
August 19-20, 2019
JOINT EVENT
conferenceseries
.com
August 19-20, 2019 Vienna, Austria
&
7
th
World Heart Congress
24
th
World Congress on
Pharmacology
Salt-sensitivity-contributing factor for the development of metabolic syndrome
Irina Andronikashvili, Simonia G
and
Pantsulaia N
Tbilisi State Medical University, Georgia
Statement of the Problem
: It is known that and salt loading not only increases blood pressure (BP) but causes
cardiovascular damage in animals and humans. Recent clinical studies have demonstrated that metabolic syndrome
(MS) increases the salt sensitivity of BP. There is also known that salt sensitivity increases with age.
Purpose
: The purpose of study was to assess an association between salt-sensitive hypertension and metabolic
syndrome in the elderly.
Materials &Methods
: The study enrolled a total of 158 ethnically Georgian patients of stage I essential hypertension
(JNC VIII). 72 of them where middle-aged (38-62 year old, 42 females and 30 males) and 86 where elderly (65-75
years old, 47 females and 39 males). Anthropometry, blood pressure monitoring, and 24 hr urinary sodium excretion
were performed. All subjects were tested for salt-sensitivity. MS was classified as recommended by the International
Diabetes Federation-IDF9.
Findings
: Our results have shown that all subjects consumed high amount of sodium chloride. Salt sensitivity
was detected in 41 (57%) of hypertensive middle-aged (24 i.e. 58.5% of them were females) and in 62 (72%) of
hypertensive elderly patients (44 i.e., 70.9% females). MS was detected in 18 (25%) of hypertensive middle-aged (11
(61%), of them were females and 14 (77.7%) were salt-sensitive) and 46 (53.4%) of hypertensive elderly patients (34
(73.9%) of them were females and 39 (84.7%) were salt-sensitive). A high prevalence of salt-sensitive hypertension
was revealed in women and positive correlation of salt-sensitivity with age was found (r=0.64, p<0.05).
Conclusions
: High incidence of salt-sensitivity and prevalence of salt-sensitive hypertension associated with high
sodium intake has been detected in Georgian hypertensive subjects. High sodium consumption in salt-sensitive
hypertensive patients of Georgian nationality is closely linked with higher incidence of MS. There is a high prevalence
of metabolic syndrome in the elderly, especially in women.
Recent Publications:
1.
Singer, M., Deutschman, C., Seymour, C., Shankar-Hari, M., Annane, D., Bauer, M., Bellomo, R., Bernard, G.,
Chiche, J., Coopersmith, C., Hotchkiss, R., Levy, M., Marshall, J., Martin, G., Opal, S., Rubenfeld, G., van der
Poll, T., Vincent, J. and Angus, D. (2016). TheThird International Consensus Definitions for Sepsis and Septic
Shock (Sepsis-3). JAMA, 315(8), p.801-810.
2.
Masson, S., Caironi, P., Fanizza, C., Thomae, R., Bernasconi, R., Noto, A., Oggioni, R., Pasetti, G., Romero, M.,
Tognoni, G., Latini, R. and Gattinoni, L. (2015). Erratum to: Circulating presepsin (soluble CD14 subtype) as a
marker of host response in patients with severe sepsis or septic shock: data from the multicenter, randomized
ALBIOS trial. Intensive Care Medicine, 41(9), pp.12-20.
3.
Koch, A., Nilsen, R., Eriksen, H., Cox, R. and Harthug, S. (2015). Mortality related to hospital-associated
infections in a tertiary hospital; repeated cross-sectional studies between 2004-2011. Antimicrobial Resistance
and Infection Control, 4(57).
4.
Komorowski, M., Celi, L., Badawi, O., Gordon, A., and Faisal, A. (2018). The Artificial Intelligence Clinician
learns optimal treatment strategies for sepsis in intensive care. Nature Medicine 24: 1716-1720.
Irina Andronikashvili et al., Clin Pharmacol Biopharm, Volume 08