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Volume 7, Issue 4 (Suppl)
Clin Exp Pharmacol
ISSN: 2161-1459 CPECR, an open access journal
Pharmacology Congress 2017
July 24-25, 2017
July 24-25, 2017 Melbourne, Australia
8
th
World Congress on
Pharmacology and Toxicology
3,4-methylenedioxymethamphetamine-induced neurotoxicity improves following exercise in the
hippocampus of adult rats
Sara Soleimani Asl Koolani
1,2
, Alireza Gharebaghi
3
, Iraj Amiri
2
, Iraj Salehi
3
, Siamak Shahidi
3
and Alireza Komaki
3
Hamadan University of Medical Sciences, Iran
3
,4-methylenedioxymethamphetamine (MDMA) or ecstasy impairs the learning and memory. As the exercise can improve
the memory, herein we investigated the effects of treadmill exercise on memory and long term potentiation in relation to
apoptosis, neurotrophic factors and stress oxidative in the hippocampus of MDMA-treated rats. Male Wistar rats received
multiple injections of MDMA and exercised for one month on a treadmill. Long Term Potentiation (LTP) and memory
function were assessed using electrophysiology and Morris water maze. Lipid peroxidation and expression of caspase 3 and
Brain Derived Neurotrophic Factor (BDNF) were examined by thiobarbituric acid assay test and western blot, respectively.
Treadmill exercise could improve MDMA-induced LTP disruption and memory impairment. Caspase 3 expression decreased
in the exercise group compared to MDMA group. BDNF expression decreased in MDMA group and treadmill exercise could
increase that. Exercise caused the reduction in lipid peroxidation in the hippocampus. Exercise seems could be a useful strategy
for treating memory impairment through up-regulation of BDNF and decrease in apoptosis in the hippocampus.
s.soleimaniasl@umsha.ac.irClin Exp Pharmacol 2017, 7:4 (Suppl)
DOI: 10.4172/2161-1459-C1-020