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.com
Volume 7
Pharmaceutical Regulatory Affairs: Open Access
ISSN: 2167-7689
Pharma Europe 2018
May 07-09, 2018
May 07-09, 2018 | Frankfurt, Germany
15
th
Annual European Pharma Congress
The relation between antibiotic use and changes of antimicrobial resistance at intensive care unit
Y S Chu, S Y Min, S M Yoo, Y J Jung
and
H K Jung
Veterans Health Service Medical Center, South Korea
Statement of the Problem
: Antimicrobial resistance inmajor bacterial pathogens has become a serious medical health problem.
To provide reference data or guideline for treatment of antimicrobial therapy, we studied a change pattern in the antimicrobial
resistance rates of clinically important microorganisms at a veteran’s hospital. In general, higher resistance rates are observed
among intensive-care-unit (ICU) isolates than non-ICU isolates. Antimicrobial resistance is an emerging problem for ICU.
Therefore, we also studied the trend of antibiotic consumption in ICU at the same hospital between 2012 and 2016.
Methodology & Theoretical Orientation
: Susceptibility data were collected from Seoul VHS Hospital’s EMR (Electronic
Medical Record) system and antimicrobial resistance monitoring system annual report between 2012 and 2016. We used days
of therapy (DOT) to calculate the annual antibiotic consumption for 17 antibiotic groups, retrospectively.
Findings:
Total number of detected bacteria in the medical center was 96,410. Frequently isolated organisms in decreasing
order were
Staphylococcus
aureus (12%),
Pseudomonas spp
. (10%),
Acinetobacter spp
. (10%),
Klebsiella spp
. (9%). Methicillin-
resistant
S. aureus
(MRSA), vancomycin-resistant
S. aureus
(VRSA), vancomycin-resistant Enterococcus spp. (VRE),
multidrug-resistant
P. aeruginosa
(MRPA), multidrug-resistant Acinetobacter baumannii (MRAB) and carbapenem-
resistant Enterobaterceae (CRE, Klebsiela pneumoniae) were isolated at 75~80%, 0%, 12~37%, 10~15%, 55~68% and 2~15%,
respectively; the resistance rate increased gradually. Average annual antibiotic consumption during 2012–2016 was 18002
DOT/year. The prescription rates of injection antibiotics are in the order of glycopeptide, carbapenem, β-Lactam/β-Lactamase
inhibitor, 3
rd
generation cephalosporin, 1
st
generation cephalosporin and quinolone. However, no statistically significant
change in the total amount of antibiotics was observed during the study period. Consumption of 2
nd
generation cephalosporin,
lincosamide, monobactam and aminoglycoside was significantly decreased, while that of β -lactam/β -lactamase inhibitor,
3
rd
and 4
th
generation cephalosporin, carbapenem, quinolone, polymyxin, glycycline and oxazolidinone with broad spectrum
increased significantly.
Conclusion& Significance:
High rates of antibiotic consumption were associated with high resistance rates of microorganisms.
The increase of multidrug-resistant microorganisms requires an update of guidelines and a more strict control of antibiotics.
Recent Publications
1. Ji M, et al. (2017) Trends in microorganisms isolated from blood cultures at a veterans hospital from 2012 to 2015.
Journal of Laboratory Medicine and Quality Assurance 39(3):141–146.
2. Bryce E A and J A Smith (2015) Focused microbiological surveillance and Gram-negative beta-lactamase-mediated
resistance in an intensive care unit. Infection Control: Hospital Epidemiology 16(6):331–334.
3. Kang C-I (2015) Antimicrobial therapy for infections caused by multidrug-resistant Gram-negative bacteria. Korean
Journal of Medicine 88(5):502.
4. Jun K I et al. (2013) Trends in antibiotic use in a single university hospital. Korean Journal of Nosocomial Infection
Control 18(2):44.
5. Shin K A and S K Hong S B (2013) Change pattern of species and antimicrobial susceptibility of microorganisms
isolated from blood culture. J Exp Biomed Sci 19:245–53.
Biography
Y S Chu is a Pharmacist working on improving patients’ health through patient safety management and system improvement since four years at the Seoul VHS
Hospital, the largest veteran’s hospital in Korea. She has 15 years of experience both in hospitals and pharmacies, contributing to social healthcare and education.
quicki@naver.comY S Chu et al., Pharmaceut Reg Affairs 2018, Volume 7
DOI: 10.4172/2167-7689-C1-031