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.com
Volume 7
Pharmaceutical Regulatory Affairs: Open Access
ISSN: 2167-7689
Pharma Europe 2018
May 07-09, 2018
May 07-09, 2018 | Frankfurt, Germany
15
th
Annual European Pharma Congress
Investigation of lidocaine-containing NLC systems for dermal application
Mónika Bakonyi, Szilvia Berkó
and
Erzsébet Csányi
University of Szeged, Hungary
T
opically applied anaesthetics are employed in order to eliminate pain caused by needle insertion and injection, thus
ameliorating patient compliance. Furthermore, they are devoid of symptoms of superficial trauma and local reaction.
Therefore, the aim of this work was to develop a new formulation of lidocaine, proposed to improve its clinical effectiveness
in topical anaesthesia in terms of both enhanced anaesthesia and a prolonged duration of action. For this purpose, we
incorporated lidocaine in nanostructured lipid carriers (NLC). Particle size and zeta potential measurements, Fourier
transform infrared spectroscopy and Raman spectroscopy were performed to characterize the NLC system. Furthermore,
DSC and XRD measurements were conducted to investigate lipid crystallization which plays a very important role in the
performance of NLC carriers. Additionally, membrane diffusion and penetration studies were completed
in vitro
and
ex vivo
,
followed by measurements on skin hydration and transepidermal water loss
in vivo
. Our results lead us to the conclusion
that the developed nanostructured lipid carrier is a promising vehicle for the topical delivery of lidocaine. The penetration of
the NLC formulation was remarkable through heat separated epidermis after 24 hours, and the observed skin hydrating and
occlusive effect also makes this formulation a favourable dermal carrier system.
Recent Publications
1. Ribeiro L N, et al. (2016) Nanostructured lipid carriers as robust systems for topical lidocaine-prilocaine release in
dentistry. European Journal of Pharmaceutical Sciences 93: 192–202.
2. Puglia C, et al. (2011) Development, characterization, and
in vitro
and
in vivo
evaluation of benzocaine- and lidocaine-
loaded nanostructrured lipid carriers. Journal of Pharmaceutical Sciences 100(5):1892–1899.
3. Pathak P and M Nagarsenker (2009) Formulation and evaluation of lidocaine lipid nanosystems for dermal delivery.
AAPS PharmSciTech 10(3):985–92.
4. Muller R H, M Radtke, and S A Wissing (2002) Solid lipid nanoparticles (SLN) and nanostructured lipid carriers
(NLC) in cosmetic and dermatological preparations. Advanced Drug Delivery Reviews 54(1):131–55
Biography
Mónika Bakonyi completed her Master’s degree in Pharmaceutical Sciences in 2015 at University of Szeged. Since 2015, she is a PhD student at the Institute of
Pharmaceutical Technology and Regulatory Affairs of the University of Szeged. Her research focuses on transdermal delivery of active agents, active and passive
penetration enhancement techniques and electroporation. Her studies include experiments with Franz cell diffusion method, tape stripping method, Corneometer
and Tewameter, ATR–FTIR and Raman spectroscopy. She has done a three month internship at the University of Freiburg, learning liposomes preparing and
evaluating methods
.
monika.bakonyi@gmail.comMónika Bakonyi et al., Pharmaceut Reg Affairs 2018, Volume 7
DOI: 10.4172/2167-7689-C1-031