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Pharma & Clinical Pharmacy Congress 2016
November 07-09, 2016
Volume 5 Issue 4(Suppl) Clin Pharmacol Biopharm
ISSN: 2167-065X CPB, an open access journal
conferenceseries .com
November 07-09, 2016 Las Vegas, Nevada, USA
4th International
Pharma & Clinical Pharmacy Congress
Wshar Ali Ismael et al., Clin Pharmacol Biopharm 2016, 5:4(Suppl)
Determination of some nitroaromatic compounds and some related pharmaceutical compounds
using flow injection-chemiluminescence method
Wshar Ali Ismael and Faizullah A Tofiq
Salahaddin University, Iraq
Arapid flow injection-chemiluminescence (FI-CL) method was used for determination of 4-nitrophenol and some
nitroaromatic compounds. These compounds, which have electron-donating group on the ortho and para positions,
undergo on-line reduction using a minicolumn of zinc redactor in acidic medium to their corresponding aminophenols. The
produced aminophenols were reacted with permanganate ion and polyphosphpric acid in the presence of dimethyl sulfoxide
as enhancer for the produced CL. The method extended to include some related nitroaromatic compounds of pharmacological
interest with similar structural formations representative such as metronidazole, furazolidone, nitrofurantoin and nitrazepam.
Under the optimum conditions, calibration graphs were obtained in the concentration ranges (0.020-1.50 and 2.00-8.00) μg/
ml for 4-nitrophenol, 0.50-14.0 μg/ml for metrnidazol, 0.50-100.0 μg/ml for furazolidone, 0.50-60.0 μg/ml for nitrazepam and
3.0-35.0 & 50.0-120.0 μg/ml for nirofurantoin. The method was successfully applied for the determination of these compounds
in dosage.The aim of this work was to develop a simple and rapid method for the determination of 4-nitrophenol and related
nitro-drug compounds, not requiring sophisticated instruments but giving results comparable with those obtained by the
standard methods in British pharmacopeia.
Biography
Wshar Ali Ismael has his expertise in analytical chemistry and determination of pharmaceutical formulations. He has used flow injection analysis technique in his
researches and has concluded chemiluminescence reactions in his research for detection and analysis of pharmaceutical compounds. He worked as a Lecturer in
Chemistry Department, Education College, Salahaddin University, Erbil, Iraq since 1992 until now. He taught instrumental analysis in the Chemistry Department.