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Volume 08
Journal of Alzheimers Disease & Parkinsonism
Parkinsons Congress 2018
May 14-15, 2018
May 14-15, 2018 Singapore
4
th
Global Experts Meeting on
Parkinson’s & Movement Disorders
Basal ganglionic lesions in Egyptian children: Radiological findings in correlation with etiology and
clinical manifestations
Hamada I Zehry, Shora Y Darwish, Sayed A El Zayat, Mohamed F Abdelmotey, Hassan K Gad, Hossam M Emam and Mohie El Din T Mohamed
Al-Azhar University, Egypt
Background &Aim:
In childhood, the metabolic activity of the basal ganglia is greater and they are particularly prone to injury.
Damage to the basal ganglia cells may cause problems controlling speech, movement, consciousness, muscle tone, posture and
cognition. Aim of the study to determine the etiology of basal ganglionic disorders in a sample of Egyptian children.
Method:
A cross-sectional observational study was utilized on 34 patients attended at the Pediatric Neuro Outpatient Unit of
Neurology Department at Al-Azhar University Hospitals during a period of one year from the beginning of November 2014 to
the end of November 2015. A specialized pediatric neurological sheet, cognitive assessment in children using Stanford-Binet
Intelligence Scale and Laboratory investigations were performed. The included patients were classified according to MRI into
two groups: Ganglionic group that included patients with isolated basal ganglionic lesions (n=23) and para-ganglionic group
that included patients with combined ganglionic as well as para-ganglionic lesions (n=11).
Result:
The frequency of male patients was slightly higher than the female patients in both groups without significant difference:
13 (56.5%) versus 6 (43.5%) and 10 (54.5%) versus 5 (45.5%), in ganglionic and para-ganglionic groups, respectively. Acute
ischemic stroke was the most frequent cause, which was found in 12 (35.3%) cases, followed by 10 (29.4%) had metabolic and
infectious causes and lastly 2 (5.9%) had toxic causes. The incidence of toxic causes (CO poisoning) was significantly higher
among ganglionic group compared to para-ganglionic group: 2 (8.7%) versus 0 (0.0%), respectively. According to brain MRI
imaging, bilateral basal ganglion affection was the most frequent lesions among ganglionic group 16 (69.7%). While temporal
affection [temporal was 2 (18.2%), temporoparietal were 2 (18.2%) and temporo-occipital was 1 (9.1%)] was the most frequent
lesions among para-ganglionic group 5 (45.5%).
Conclusion:
Acute ischemic stroke was the most frequent cause of basal ganglionic lesion in a sample of Egyptian children.
zehryhamada@yahoo.comJ Alzheimers Dis Parkinsonism 2018, Volume 8
DOI: 10.4172/2161-0460-C2-040