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Volume 08 Journal of Alzheimers Disease & Parkinsonism Parkinsons Congress 2018
May 14-15, 2018
May 14-15, 2018 Singapore
4th Global Experts Meeting on
Parkinson’s & Movement Disorders
Is there relationship between Toxoplasma gondii IgG seropositivity and idiopathic parkinsonism and
does it have correlation with cortisol blood level?
Ahmed Abd El Rahman Daoud, Wesam Mostafa Elgendy, Nabila Abd El Azeem Yassen, Hazem Abd El Rahman Fayed and Marwa Adel Hasby Saad
Tanta University, Egypt
Background & Aim: Some researches have linked latent toxoplasmosis and neurological diseases, so the main interest is the
probable relation between toxoplasmosis and neurological diseases such as epilepsy and parkinsonism. This study aimed to
detect the incidence of Toxoplasma gondii infection in patients with idiopathic parkinsonism and correlate it to their blood
level of cortisol.
Material &Method: This study was conducted on 30 idiopathic parkinson’s patients, 30 psychiatric patients and 30 apparently
healthy individuals. All subjects were given a questionnaire and anti-Toxoplasma IgM, anti-Toxoplasma IgG and cortisol level
were detected by ELISA.
Result: Of the 90 cases, 41.11% and 1.11% were positive for anti-Toxoplasma IgM and IgG, respectively. The percentage of
positive anti-Toxoplasma IgG cases was in healthy group (46.67%) followed by parkinsonism group (43.3%). Mean cortisol
level higher in parkinson’s group than other groups but still within normal levels. Contact to cats, drinking unfiltered water
and consuming unwashed raw vegetables was significantly higher in Toxoplasma IgG seropositive parkinson’s patients. Highest
anti-Toxoplasma IgG positive cases in parkinson’s group were detected in stage-3 of the disease.
Conclusion: A high Toxoplasma seropositivity is associated with parkinsonism. Toxoplasma gondii oocyst was the most
probable main mode of transmission of Toxoplasma gondii in idiopathic Parkinson’s patients. Toxoplasma gondii may worsen
idiopathic parkinsonism. Cortisol level was higher in parkinson’s patients; still it showed no significant relationship with
Toxoplasma gondii seropositivity.
J Alzheimers Dis Parkinsonism 2018, Volume 8
DOI: 10.4172/2161-0460-C2-040