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conferenceseries
.com
Volume 6, Issue 5 (Suppl)
J Pain Relief, an open access journal
ISSN: 2167-0846
Pain Management 2017
October 05-06, 2017
5
th
International Conference and Exhibition on
October 05-06, 2017 London, UK
Pain Research And Management
J Pain Relief 2017, 6:5(Suppl)
DOI: 10.4172/2167-0846-C1-015
Combined effect of baclofen and acamprosate in experimental models of peripheral neuropathic pain
in wistar rats
Varun Vikas Vij
Dayanand Medical College & Hospital, India
Background&Aim:
Neuropathic pain (NP) is defined as pain associated with damage or permanent alteration of the peripheral
or central nervous system. Current drug treatment for the management of neuropathic pain associated with various adverse
effects. The present study was designed to investigate the combined effect of acamprosate and baclofen in experimental model
of peripheral neuropathic pain in wistar rats.
Material &Methods:
Neuropathic pain was induced by chronic constriction injured (CCI) of sciatic nerve in rats. Acamprosate
(100 and 200 mg/kg p.o) and baclofen (10 and 20 mg/kg p.o) was given in diverse groups for 14 days starting on 7th day post
sciatic nerve ligation. Further combination of acamprosate (100 mg/kg p.o) and baclofen (10 mg/kg p.o) was also given to one
group. On 1st, 3rd, 7th, 14th and 21st day behavioral parameters like mechanical allodynia and thermal hyperalgesia were
assessed. Then animals were sacrificed on 22nd day and biochemical parameters (GSH, LPO, catalase, nitrite, SOD) were
assessed.
Results:
Ligation of sciatic nerve significantly induced mechanical allodynia and thermal hyperalgesia with increase in
oxidative stress (increase in LPO and nitrite) and decline of anti-oxidant enzyme levels (catalase, SOD, GSH) in sciatic nerve
homogenate. Acamprosate (100 and 200 mg/kg p.o) and baclofen (10and 20 mg/kg p.o) attenuated all the behavioural and
biochemical parameters alone and/or combination.
Varunkumar1982dec@gmail.com