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conferenceseries
.com
Volume 6, Issue 5 (Suppl)
J Pain Relief, an open access journal
ISSN: 2167-0846
Pain Management 2017
October 05-06, 2017
5
th
International Conference and Exhibition on
October 05-06, 2017 London, UK
Pain Research And Management
Synthesis, molecular docking and biological evaluation of some 2-substituted-6-(morpholin-4-yl)
pyridazin-3(2h)-ones as potent anti-inflammatory and analgesic agents
Jyoti Singh
1
, Ranju Bansal
1
, Vandana Saini
2
and
Ajit Kumar
2
1
Panjab University, India
2
Maharashi Dayanand University, India
I
nflammation is a body response to injury or abnormal stimulation caused by a physical, chemical or biological agent. The
first-line mode of therapeutic intervention for inflammation is non-steroidal anti-inflammatory drugs(NSAIDs). However,
the long-term use of NSAIDs produces high incidence of gastrointestinal irritation, resulting in the development of life-
threatening gastrointestinal side effects such as gastric irritation, ulceration and bleeding. Further discovery of selective COX-
2 inhibitors (coxibs) suggested safety without any ulcerogenic side effects; however, long-term use of these drugs resulted in
kidney and hepatic toxicity along with an increased risk of secondary cardiovascular effects. Therefore, development of novel
anti-inflammatory agents with an improved safety profile is still a necessity to overcome the side effects of the existing agents.
The basic approaches towards inflammation and pain treatment are constantly changing and researchers are continuously trying
to develop safer and effective anti-inflammatory drug candidates for the treatment of different inflammatory conditions such
as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, psoriasis and multiple sclerosis. Synthetic 3(2H)-pyridazinones
constitute an important scaffold for drug discovery. Docking studies suggest that introduction of morpholine moiety on the 6-
position and attachment of an amide at N-2 position of pyridazinone nucleus through a methylene spacer may lead to products
having potent analgesic
jsjyotisingh202@gmail.comJ Pain Relief 2017, 6:5(Suppl)
DOI: 10.4172/2167-0846-C1-015