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Volume 9 J Clin Exp Ophthalmol, an open access journal
ISSN: 2155-9570 Ophthalmology Summit 2018
February 26-27, 2018
February 26-27, 2018 | Berlin, Germany
19th Global Ophthalmology Summit
Sumoylation regulation of lens development
David W Li,1,2,3, Lili Gong1, Weike Ji4, Fang Yuan Liu1, Ling Wang1,2,3, Qian Nie1,2, Jia-Wen Xiang1,2, Xiao-Dong Gong1, Zigang Chen 1,2, Zhong-Wen Luo 1,
Lan Zhang1 , Xiang-Cheng Tang1, Ruili Qi1,3, Mi Deng5, Zhaoxia Huang3, Xiaohui Hu3, Quan Dong Nguyen6, and Yi-Zhi Liu1
1Zhongshan Ophthalmic Center - Sun Yat-Sen University, China
2Hunan Normal University, China
3Truhlsen Eye Institute - University of Nebraska Medical Center, USA
4Tongji Medical College - Huazhong University of Science and Technology, China
5Byers Eye Institute - Stanford University Medical Center, USA
6University of Texas Southwestern Medical Center, USA
S UMOylation is now established as one of the key regulatory protein modifications in eukaryotic cells. It regulates chromatin
organization, transcription, DNA repair, macromolecular assembly, protein homeostasis, trafficking, signal transduction,
cell differentiation and stem cell development. It also acts as a molecular mechanism mediating global changes at the cellular
and organism levels when stress conditions such as heat shock or oxidative stress occur. More importantly, SUMOylation plays
causal roles inmanymajor human diseases such as cardiovascular, neuronal diseases and cancers. In the eye, SUMOylation plays
a key role in retina development, and it has causal effects on corneal dystrophy. Our recent studies revealed that SUMOylation is
necessary to activate the p32 Pax6, the shortest isoform of Pax6, the master regulator for eye and brain development. Moreover,
our studies further revealed that sumoylation plays an important role in regulating lens differentiation. Different isforms of
SUMO are differentially expressed in the ocular lens and plays contrast roles in regulating lens differentiation. While SUMO1
promotes lens differentiation, SUMO2 and SUMO3 inhibits this process. Mechanistically, SUMO1 and SUMO2/3 can either
conjugate different transcription factors or conjugate to the same factor but with different preferred SUMOylation sites. In the
present study, we discuss the functions of different SUMO isoforms in controlling lens development.
Biography
David Wan Cheng Li received his PhD degree in Molecular and Cellular Biology from the University of Washington in Seattle, and completed his Postdoctoral
training in the Harkness Eye Institute of Columbia Medical Center in New York City. He is currently an elected One-Hundred Talent Professor in the State Key
Laboratory of Zhongshan Ophthalmic Center in Sun Yat-Sen University, an elected Lotus Scholar Professor of Cellular and Developmental Biology in Hunan Normal
University in China. He made numerous important discoveries in both eye development and ocular diseases as well as cancer research fields, published over 100
articles in PNAS, NAR, Cancer Research, CDD, Oncogene, MBC, JBC, and IOVS, etc. He has trained 30 PhD students and Postdoctoral fellows, and lectured
in a dozens of countries including German, England, USA, Japan and China. He receiverd the Outstanding Achievements Award of Cataract Research from the
National Foundation for Eye Research, USA in 2006.
David W Li et al., J Clin Exp Ophthalmol 2018, Volume 9
DOI: 10.4172/2155-9570-C1-078