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conferenceseries.com
Volume 9 J Clin Exp Ophthalmol, an open access journal
ISSN: 2155-9570 Ophthalmology Summit 2018
February 26-27, 2018
February 26-27, 2018 | Berlin, Germany
19th Global Ophthalmology Summit
Retinal pigment epithelial cell replacement strategies
Carl M Sheridan
University of Liverpool, UK
Dysfunction of Retinal Pigment Epithelial (RPE) cells and their underlying Bruch’s basement membrane leads to subsequent
photoreceptor degeneration and irreversible vision loss in several retinal pathologies including Age-related Macular
Degeneration (AMD) Subretinal transplantation of a functioning monolayer of cells to replace the damaged or lost RPE cells
is a promising area for treatment of AMD. Replacement of the atrophied RPE cell layer has previously shown some potential
in restoring visual acuity in patch autograft surgeries. The source of replacement cells (ocular and non-ocular) from induced
pluripotent cells, embryonic stem cells, mesenchymal stem cells and adult epithelial cells is the subject of widespread research
with some Phase I clinical trials underway. In addition, the choice of underlying substrates for transplant being developed
includes biological and artificial substrates that are either degradable or non-degradable. The merits and challenges currently
faced in translating the plethora of cross-discipline discovery research into clinical practice will be presented.
Recent Publications
1. Kearns V R, Tasker J, Zhuola Akhtar R, Bachhuka A et. al (2017) The formation of a functional retinal pigment
epithelium occurs on porous polytetrafluoroethylene substrates independently of the surface chemistry. J. Mater. Sci.
Mater. Med. 28(8):124.
2. Parekh M, Ferrari S, Sheridan C, Kaye S and Ahmad S (2016) Concise review: an update on the culture of human
corneal endothelial cells for transplantation. Stem Cells Translational Medicine. 5(2):258-264.
3. Branch M J Yu, W Y, Sheridan, C and Hopkinson A (2015) Isolation of Adult Stem Cell Populations from the Human
Cornea. In: Rich, I. N. Stem Cell Protocols. Doi: 10.1007/978-1-4939-1785-3.
4. Doherty KG, Oh J S, Unsworth P, Bowfield A, Sheridan CM et. al (2013) Polystyrene surface modification for localized
cell culture using a capillary dielectric barrier discharge atmospheric-pressure microplasma jet. Plasma Processes and
Polymers. 10(11):978-989.
5. Mason S L, Stewart RM, Kearns V R, Williams R L and Sheridan CM (2011) Ocular epithelial transplantation: current
uses and future potential. Regen Med. 6(6):767-782.
Biography
M Sheridan is an internationally renowned Cell Biologist with research experience in Ocular Cell Biology since 1991. His areas of focus have centered on ocular
wound healing and cell transplantation research with published papers concerning the ocular surface, cornea, outflow pathway as well as retinal pathologies
such as proliferative vitroretinopathy (PVR) and age-related macular degeneration (AMD). He has published and reviewed for almost all Ophthalmology scientific
journals as well as chaired at international Ophthalmology conferences. He has a keen interest in both Tissue Engineering and Regenerative Medicine approaches
to prevent and restore sight loss and is passionate that cross discipline research is key to achieving this goal.
Carl M Sheridan, J Clin Exp Ophthalmol 2018, Volume 9
DOI: 10.4172/2155-9570-C1-078