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Volume 2, Issue 2 (Suppl)

Optom open access

ISSN: 2476-2075 OMOA, an open access journal

Ophthalmologists 2017

September 25-26, 2017

September 25-26, 2017 Dubai, UAE

11

th

Global

Ophthalmologists Annual Meeting

Long term follow-up of patients affected by dome shaped macula associated with serous detachment

of the foveal neuroepithelium and treated with photodynamic therapy

Arjeta Grezda

1

and Ilir Arapi

1, 2

1

University Hospital Center Mother Terea, Albania

2

Polytechnic University of Marche, Italy

Introduction & Objectives:

Foveal serous retinal detachment (SRD) in patients with dome shaped macula (DSM) represents

the most frequent reason of impaired vision and referral to eye care units. The aim of this study is to investigate the role of

photodynamic therapy (PDT) as a therapeutic modality in myopic patients affected by DSM associated with foveal SRD.

Methods:

The study was designed as a retrospective interventional case series. The medical records of 18 consecutive myopic

patients (20 eyes) with DSM associated with foveal SRD and treated with PDT were retrospectively reviewed. Best corrected

visual acuity (BCVA), refractive error, fluorescein angiography (FA), indocyanine green angiography (ICGA) and enhanced

depth imaging (EDI) optical coherence tomography (OCT) findings were evaluated. Visual gain and loss were considered as

increasing or decreasing of two or more lines of best corrected visual acuity (BCVA) respectively and eyes with fluid resolution

were considered as responsive to PDT.

Results:

All eyes underwent several PDT treatments with a median of 3 (1

st

, 3

rd

quartiles 2; 3, 75; range: 1 to 7) and with a

median follow-up time of 22 months (1

st

, 3

rd

quartiles 12; 40; range 4 to 55). At the last follow-up 7 eyes (35%) showed complete

resolution of the foveal SRD being considered as responsive to PDT. At last follow-up visit 5 eyes (25%) showed an increased

BCVA, 13 eyes (65%) maintained a stable BCVA, while 2 eyes (10%) had a decrease in their BCVA. Statistical analysis showed

that BCVA improvement was significantly higher in eyes responding to PDT (p=0.027). The median baseline hypocyanescent

macular area observed during late ICGA frames resulted significantly lower [2.6 mm² (1

st

, 3

rd

quartiles 2.3; 2.8 mm

2

; range

1.61-3.28 mm

2

)] in the group of patients that responded to PDT and had an increase of ≥2 Snellen lines in BCVA versus

the remaining ones that were considered non-responders [8.1 mm

2

(1°; 3° quartile 5.1; 10.2 mm

2

; range 4.50-14.26 mm

2

)]

(p<0.001).

Conclusions:

Our data suggest that myopic eyes associated with DSM and foveal SRD might be responsive to PDT showing

total resolution of fluid accumulation and positive BCVA changes, if baseline ICGA findings show evidence of a limited

hypocyanescent macular area.

arjeta_demi@yahoo.com

Arjeta Grezda et al., Optom open access 2017, 2:2 (Suppl)

DOI: 10.4172/2476-2075-C1-005