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.com
Volume 2, Issue 2 (Suppl)
Optom open access
ISSN: 2476-2075 OMOA, an open access journal
Ophthalmologists 2017
September 25-26, 2017
September 25-26, 2017 Dubai, UAE
11
th
Global
Ophthalmologists Annual Meeting
Long term follow-up of patients affected by dome shaped macula associated with serous detachment
of the foveal neuroepithelium and treated with photodynamic therapy
Arjeta Grezda
1
and Ilir Arapi
1, 2
1
University Hospital Center Mother Terea, Albania
2
Polytechnic University of Marche, Italy
Introduction & Objectives:
Foveal serous retinal detachment (SRD) in patients with dome shaped macula (DSM) represents
the most frequent reason of impaired vision and referral to eye care units. The aim of this study is to investigate the role of
photodynamic therapy (PDT) as a therapeutic modality in myopic patients affected by DSM associated with foveal SRD.
Methods:
The study was designed as a retrospective interventional case series. The medical records of 18 consecutive myopic
patients (20 eyes) with DSM associated with foveal SRD and treated with PDT were retrospectively reviewed. Best corrected
visual acuity (BCVA), refractive error, fluorescein angiography (FA), indocyanine green angiography (ICGA) and enhanced
depth imaging (EDI) optical coherence tomography (OCT) findings were evaluated. Visual gain and loss were considered as
increasing or decreasing of two or more lines of best corrected visual acuity (BCVA) respectively and eyes with fluid resolution
were considered as responsive to PDT.
Results:
All eyes underwent several PDT treatments with a median of 3 (1
st
, 3
rd
quartiles 2; 3, 75; range: 1 to 7) and with a
median follow-up time of 22 months (1
st
, 3
rd
quartiles 12; 40; range 4 to 55). At the last follow-up 7 eyes (35%) showed complete
resolution of the foveal SRD being considered as responsive to PDT. At last follow-up visit 5 eyes (25%) showed an increased
BCVA, 13 eyes (65%) maintained a stable BCVA, while 2 eyes (10%) had a decrease in their BCVA. Statistical analysis showed
that BCVA improvement was significantly higher in eyes responding to PDT (p=0.027). The median baseline hypocyanescent
macular area observed during late ICGA frames resulted significantly lower [2.6 mm² (1
st
, 3
rd
quartiles 2.3; 2.8 mm
2
; range
1.61-3.28 mm
2
)] in the group of patients that responded to PDT and had an increase of ≥2 Snellen lines in BCVA versus
the remaining ones that were considered non-responders [8.1 mm
2
(1°; 3° quartile 5.1; 10.2 mm
2
; range 4.50-14.26 mm
2
)]
(p<0.001).
Conclusions:
Our data suggest that myopic eyes associated with DSM and foveal SRD might be responsive to PDT showing
total resolution of fluid accumulation and positive BCVA changes, if baseline ICGA findings show evidence of a limited
hypocyanescent macular area.
arjeta_demi@yahoo.comArjeta Grezda et al., Optom open access 2017, 2:2 (Suppl)
DOI: 10.4172/2476-2075-C1-005