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conferenceseries.com
October 20-22, 2016 Rome, Italy
11th International Conference and Expo on
Nanoscience and Molecular Nanotechnology
Volume 7, Issue 5 (Suppl) J Nanomed Nanotechnol 2016
ISSN: 2157-7439 JNMNT an open access journal NanoScience 2016
October 20-22, 2016
In vitro controlled release of 5-FU drug from a stimuli-responsive microgel/liposome biomaterials at different
temperatures
Damla Ülker1, Inci Barut2, Erol Şener 2and Vural Bütün1
1Eskisehir Osmangazi University, Turkey
2Anadolu University, Turkey
Poly (ethylene glycol) stabilized stimuli-responsemicrogels have beenused as a drug carrier and a release systemdue to its low toxicity
and high biocompatibility nature. They are promising material for the advancement of specific drugs carriers like cancer drugs.
They have huge pore size which can be decreased by varying cross-linker ratio. They might be modified with liposome and magnetic
nanoparticles as well. Liposome/microgel stimuli-response drug release system may provide better application opportunities such
as delivery of multiple components and imaging agents, diagnostic and therapies. In this study, multi-response liposome/microgel
hybrid drug delivery and targeting system was synthesized. 5-fluorouracil (5-FU) drug was loaded into liposomes in aqueous media,
and then a water soluble monomer based multi-responsive microgel hosting liposome-5-FU system was synthesized. Finally, 5-FU
loaded hybrid system was covered with magnetic Fe3O4 nanoparticles in order to provide a response to magnetic field. This hybrid
system was used in vitro studies as a drug carrier for a target and controlled drug release system in phosphate buffer solution (pH
7.4) incubated at 37°C and 42°C and physiological saline solution incubated at 37°C. All microgel, liposome and liposome/microgel
systems were characterized by using dynamic light scattering, zetapotentiometer, transmission electron microscopy. Magnetic Fe3O4
nanoparticles covered liposome/microgel hybrid system was characterized by using TEM. The release of 5-FU from liposome-
microgel hybrid system was analyzed using high-performance liquid chromatography with ultraviolet spectrophotometer detector
at 266 nm.
Acknowledgement: ESOGU and the Scientific and Technological Research Council of Turkey (TUBITAK) are thanked for financial
supports (GN: 201619C104 and 115Z726, respectively)
Biography
Damla Ülker is a PhD student at the Department of Polymer Science and Technology of Eskisehir Osmangazi University. She works in various projects based on
polymer synthesis and their application studies. Her recent research is based on “Synthesis and Characterization of Novel Microgels, Nanometals, Nanocomposites,
Block Copolymer Stabilizers for Related Application Studies”. She has great experience on nanometal dispersion preparation, ATRP chemistry and heterogeneous
polymerization techniques including both emulsion and dispersion polymerizations.
Damla Ülker, J Nanomed Nanotechnol 2016, 7:5 (Suppl)