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conferenceseries.com
October 20-22, 2016 Rome, Italy
11th International Conference and Expo on
Nanoscience and Molecular Nanotechnology
Volume 7, Issue 5 (Suppl) J Nanomed Nanotechnol 2016
ISSN: 2157-7439 JNMNT an open access journal NanoScience 2016
October 20-22, 2016
Polymeric nanochannels for studing DNA and for counting natural and engineered nanoparticles
Elena Angeli
Univerisity of Genova, Physics Department, Genova, Italy
Single and multiple nanochannels’ devices are powerful tools whose exploitation covers various field of application. Slightly
modifying the characteristics of a basic structure like a nanochannel, it is possible to investigate a variety of different phenomena:
conformational change in biopolymers, nanoparticles’ translocation processes. For example: devices with multiple nanochannels can
be used for stretching long DNAmoleucles for bar coding applications [1-2], while nanochannels interrupted by series of deep regions
can be used as entropic traps for studying the dynamics conformational changes in biopolymers [3]. Devices with short single channels
are used for counting and sizing nanoparticles one-by-one exploting an electro-optical tracking method recently developed by our
laboratory. This technique is based on the simultaneous acquisition of electrical traces and optical tracks of nanoparticles crossing
the nanochannel. This multimodal analysis approach greatly increases the reliability of these sensors, compared to conventional
monomodal approaches, in counting and sizing nanoparticles of different nature. The versatility of these nanodevices makes them
very valuable tools for several areas of Nanotechnology.
1. C. Manneschi et al., Macromolecules 46, 4198 (2013).
2. C. Manneschi et al., Biomicrofluidics 8, 064121 (2014)
3. E. Angeli et al., Lab on chip 11, 2625 (2011)
4. E. Angeli et al., Nano Letters 15 (9), 5696 (2015)
Biography
Elena ANGELI received her PhD in Physics from the University of Modena and Reggio Emilia, then she moved to the University of Genova where she started
working on Nanofluidics for Biomedical applications, at Nanomed Labs. She has been developing innovative technologies and nanofluidic devices, mainly polymeric,
for manipulating DNA molecules at single molecule level. Besides her activity on nanofluidic lab-on-chips, she is also exploring the field of polymeric devices for
culturing and handling cells of oncological interest.
Elena Angeli, J Nanomed Nanotechnol 2016, 7:5 (Suppl)