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conferenceseries.com
October 20-22, 2016 Rome, Italy
11th International Conference and Expo on
Nanoscience and Molecular Nanotechnology
Volume 7, Issue 5 (Suppl) J Nanomed Nanotechnol 2016
ISSN: 2157-7439 JNMNT an open access journal NanoScience 2016
October 20-22, 2016
Albumin-gold nanorods based core-shell nanoplatforms for cancer theranostics
Hsien Ting Chiu, Chung Hao Chen, Meng Lin Li, Chi Shiun Chiang and Yu Feng Huang
National Tsing Hua University, Taiwan
Over the past two decades, the rapid development of albumin- and gold nanostructures-based nanoplatforms offer promising
solutions to address numerous scientific difficulties in cancer research such as drug delivery, tumor targeting and cancer therapy.
In this study, a hybrid system (NR@SA) was designed for theranostic nanomedicine through chemically cross-linking of serum
albumin (SA) shell outside the core of gold nanorod (Au NR). A tremendous amount of anticancer drugs, doxorubicin (DOX) could
also be encapsulated inside the SA shell via physical adsorption during the formation of NR@SA:DOX. Our results demonstrated
that the SA shell exhibited a great impact on the photoacoustic signal generation, leading to a strong contrast enhancement in
photoacoustic imaging of tumor cells. Delivered NR@SA:DOX with higher DOX loading exhibited greater killing efficacy while the
photothermal effect induced by the near-infrared laser irradiation also greatly improved the therapeutic efficacy of DOX against
tramp-C1 prostate carcinoma in vitro and in vivo. These findings suggest that the development of core-shell nanoplatform, NR@SA
is highly promising as an integrated theranostic nanoagent for further clinical applications.
Biography
Hsien Ting Chiu has completed his Bachelor’s degree from National Tsing Hua University at the Department of Biomedical Engineering and Environmental
Sciences in 2012. He is now a PhD student in National Tsing Hua University in the Department of Biomedical Engineering and Environmental Sciences. His
research is focused on nanomaterial design for cancer application.
Hsien Ting Chiu et al., J Nanomed Nanotechnol 2016, 7:5 (Suppl)