nanoscience-2016_scientifictracks-workshop

29 / 34

Page 59
Notes:
conferenceseries.com
October 20-22, 2016 Rome, Italy
11th International Conference and Expo on
Nanoscience and Molecular Nanotechnology
Volume 7, Issue 5 (Suppl) J Nanomed Nanotechnol 2016
ISSN: 2157-7439 JNMNT an open access journal NanoScience 2016
October 20-22, 2016
Synthesis and Characterization of Superparamagnetic Colloidal Nanoparticles for Theranostics in Oncology
Elena Kuchma
Southern Federal University, Russia
Nowadays one of the most important research field is the application of magnetic nanoparticles for theranostics in oncology
(contrast agent forMRI (Magnetic Resonance Imaging) and activematerial forMagneticHyperthermia treatment). Development
of novel advanced nanomaterials for biomedical applications is limited to a great extent by the lack of cutting-edge characterization
techniques of both nanoparticles themselves and their spatial distribution in biological tissues after administration. A possibility
of fine tuning of these nanoparticles characteristics in size, shape and specific magnetic characteristics should be realized. For
the manufacture of colloidal magnetic nanoparticles having tuneable magnetic and biochemical properties advanced micro-wave
synthesis technique was used, thus preparing a bases for future personalized nanomedicine platform. To get detailed insight into the
relationships between parameters of colloidal magnetic nanoparticles ( size, morphology, stoichiometry, type of surfactant covering
the nanoparticles) and their magnetic and biochemical properties advanced in-situ x-ray spectroscopic methods were applied. Iron
oxide based colloidal magnetic nanoparticles for theranostics in oncology are promising candidates for nanomedical applications as
one could use them both for diagnostics (as a contrast agent in MRI ) and simultaneously for therapy (as active agent for magnetic
hyperthermia of tumour tissues ). In the present study advanced synchrotron radiation x-ray spectroscopiс methods were used
for in-situ study of colloidal magnetic nanoparticles in solution, reproducing their “natural” conditions in biological tissues. High-
energy-resolution XANES and non-resonant XES obtained at ESRF ID26 beamline were applied to study the atomic and electronic
structures of the colloidal nanoparticles in both occupied and unoccupied electronic states regions. High energy resolution XAFS,
obtained through selective fluorescence detection was treated by using of advanced FitIt theoretical approach to obtain the 3D local
structure parameters exploiting the improved full-potential FDMNES code.
Biography
Elena Kuchma graduated from Faculty of Physics at Southern Federal University of Russia. She is a Master student at Southern Federal University and assistant
for director of Smart Materials International Research Center.
Elena Kuchma, J Nanomed Nanotechnol 2016, 7:5 (Suppl)