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.com
Volume 8
Medicinal Chemistry
ISSN: 2161-0444
Medicinal Chemistry 2018
June 14-15, 2018
June 14-15, 2018 | Barcelona, Spain
10
th
World Congress on
Medicinal Chemistry and Drug Design
Synthesis of 2-substituted pyrazolines as potential antimalarial and antimicrobial agents
Nitendra K Sahu
SRK University, India
A
novel series of 2-substituted pyrazolines were synthesized and evaluated for
in vitro
antimalarial efficacy against
chloroquine sensitive (MRC-2) as well as chloroquine resistant (RKL9) strains of
Plasmodium falciparum
. Compounds
were confirmed by elemental analyses, IR, 1H NMR and 13C NMR spectral data. Compounds 5o (IC50=0.032 μM for MRC-2
and IC50=0.209 μM for RKL-9) displayed better antiplasmodial activity than chloroquine. The antibacterial and antifungal
evaluations were also conducted, compounds 5d and 5k exhibited better antibacterial activity against
S. aureus, B. subtilis,
E. coli
and
P. aeruginosa
than ciprofloxacin. Antifungal activity of compound 5n against A. niger (MIC-3.36 μg/ml) and C.
albicans (MIC-6.9 μg/ml) was found to be better than the standard drug fluconazole.
nksahupharma@gmail.comMed chem (Los Angeles) 2018, Volume 8
DOI: 10.4172/2161-0444-C1-040