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.com
Volume 8
Medicinal Chemistry
ISSN: 2161-0444
Medicinal Chemistry 2018
June 14-15, 2018
June 14-15, 2018 | Barcelona, Spain
10
th
World Congress on
Medicinal Chemistry and Drug Design
Novel drug discovery approaches for cancer metabolism: old paradigm with new perspective
Mustafa Guzel
İ
stanbul Medipol University,
İ
stanbul
C
ancer still remains the second leading cause of death in the world after heart disease and cardiovascular complications.
Moreover, survivors of cancer still continue to suffer from symptoms of pain, fatigue, and depression despite existing
treatment advances for cancer treatment. Even though numerous pharmacological therapies have been developed in the past
decade, the advantage of new treatment options remains important in the fight against this deadly disease. It is now well
understood that protein kinases play key roles in the growth and survival of cancer cells by regulating their onset of DNA
synthesis, their response to DNA damage and their entry, progression, and exit from mitosis. Clinical validations prove that
protein kinases are an attractive class of therapeutic drug targets for cancer as demonstrated with the recent approval of six
protein kinase inhibitors. The Warburg effect describes the particular reliance of cancer cells on glycolysis for energy. Increased
glycolysis and acid resistance have been postulated to be an essential part of carcinogenesis, conferring a significant growth
advantage as well as promoting typical tumor progression. Targeting accelerated glycolysis in cancer cells is a new promising
modality for treatment of cancer. Inhibition of glycolysis can be done without significant side effects, and such treatment will
be additive to most known cancer therapies. Recent studies show that Methyl Jasmonate reveals promising results for treatment
of cancer. During the presentation the role of Aerobic Glycolysis for tumor growth and small molecule drug discovery and
development efforts as well as their therapeutic applications for oncological indications will be highlighted.
mguzel@medipol.edu.trMed chem (Los Angeles) 2018, Volume 8
DOI: 10.4172/2161-0444-C1-040