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conferenceseries
.com
Volume 8
Medicinal Chemistry
ISSN: 2161-0444
Medicinal Chemistry 2018
June 14-15, 2018
June 14-15, 2018 | Barcelona, Spain
10
th
World Congress on
Medicinal Chemistry and Drug Design
Synthesis of dihydroquinoline carboxamide derivatives, as anti-tubercular agents
Gautam Kumar
and
Sanjay M Jachak
NIPER, India
Q
uinoline derivatives have wide applicability in various fields of medicinal, industrial, bio-organic and synthetic organic
chemistry. Sodium trifluromethanesulfonate, and glacial acetic acid efficiently catalyzed the synthesis of dihydroquinoline
via Friedländer annulation. The synthesized dihydroquinoline analogues coupled with different amines by the use of coupling
reagent gave dihydroquinoline carboxamide derivatives inmoderate to good yields.The synthesized compounds were evaluated
for the anti-tubercular activity and cytotoxic activities. The structure of all the novel compounds were confirmed using 1H
NMR, 13C NMR and mass spectral techniques.
Kumargautamgalaxy@gmail.comMed chem (Los Angeles) 2018, Volume 8
DOI: 10.4172/2161-0444-C1-040