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conferenceseries
.com
Volume 9
Journal of Analytical & Bioanalytical Techniques
Mass Spectra & Analytika 2018
September 19-20, 2018
September 19-20, 2018 Singapore
World Congress on
Mass Spectrometry and Analytical Techniques
J Anal Bioanal Tech 2018, Volume 9
DOI: 10.4172/2155-9872-C2-031
Recent advances in tandem mass spectrometry, rational application workflows for research and
development of pharmaceuticals and understanding future needs
Dev Kant Shandilya
Eisai Pharmaceuticals India Pvt. Ltd, India
M
ass Spectrometry (MS) is an analytical technique/tool can identify and quantify verity of organic, inorganic and
biological compounds. In pharmaceutical research and development mass spectrometry plays a key role from initial
to late development phases for all type of drug molecules; small organic molecules, peptides, monoclonal antibodies (mAbs),
Antibody Drug Conjugates (ADC) and Biosimilar (BS). Use of advanced mass spectrometry instruments is continuously
increasing in analytical research laboratories, especially tandem mass spectrometry with high resolution mass analyzers, ion
mobility and advancement in fragmentation techniques. These recent advances features along with rational workflows allow
researchers for in-depth researchwithminimumexperiments. Use of rationally designedworkflows further helps to increase the
productivity and quality of the research data. So the present study focused on the recent advances, rational analysis workflows
and for utilization of technological advancement to fulfill research needs for various research arenas. Recent advances covered
during study are; Ion Mobility (IM) feature used to drive the Collision Cross Section (CCS) of molecules under pre-set gas
and temperature conditions, low and high energy dissociations, some other rational lab workflows with case studies using
wide verity of drug molecules. For better understanding of workflows and latest technological advancement some of basic
interpretation rules and other rational interpretation tools also discussed during the study. Discussed recent advances, rational
workflow and case studies will surely guide researcher for better utilization of existing technology and to predict technology
enhancement needed for future.
d-shandilya@eisai.co.in