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conferenceseries
.com
Volume 5, Issue 3 (Suppl)
J Infect Dis Ther, an open access journal
ISSN:2332-0877
Infectious Diseases 2017
August 21-23, 2017
3
rd
Annual Congress on
Infectious Diseases
August 21-23, 2017 San Francisco, USA
Pragya Khanna, J Infect Dis Ther 2017, 5:3 (Suppl)
DOI: 10.4172/2332-0877-C1-027
A study of clinical profile of HIV in pediatric patients
Pragya Khanna
Gujarat Medical Education and Research Society, India
Purpose:
To evaluate the modes of clinical presentation and transmission of HIV, opportunistic Infection’s (OI’s), association
of tuberculosis in HIV and its relation with CD4, clinical and immunological response of ART and its side effects and failure.
Methods:
Prospective study on children living with HIV/AIDS (CLHA) >18 months to 12 years of age admitted and attended
in pediatric department. Complete history, physical examination, diagnosis age, symptoms and opportunistic infections, serial
CD4 count every 6 month were taken into consideration.
Results &Discussion:
All CLHAwere affected withOI’s after 7 years when diagnosed. 75.52% (219 patients) of newly diagnosed
CLHA were symptomatic at the time of presentation. Maximum numbers of symptomatic CLHA fall in WHO clinical stage
3 and based on CD4 count maximum numbers of CLHA have either no or mild immunosuppression. So, it concludes that
CLHA having severe clinical disease can have no or mild immunosuppression. Therefore, CD4 count and clinical staging
should be done before starting ART. Most common presentations were fever and weight loss followed by chronic cough and
oral thrush and most common sign was hepatospleenomegaly. 52 CLHA (37.58%) suffered from TB had CD4 count less than
500. So, at low CD4 counts it was an OI and high CD4 count it was more of a co-infection. 79% of CLHA were anemic and out
of them 6% were severely anemic required blood transfusion. 58% CLHA of >5 years were on PCP prophylaxis. Most common
opportunistic infections were bacterial pneumonia and oral candidiasis. Most common side effect of ART was abnormal liver
function test. 60% patients on ART substituted as because of CLHA were also having AKT. Only one CLHA was switched to
2nd line ART because of immunological failure. During the study period 6% patients died and 11% CLHA are transferred to
link centers.
Biography
Pragya Khanna is a Class-1 Pediatrician at General Hospital Vadnagar and Assistant Professor at Gujarat Medical Education and Research Society (GMERS)
Medical College Vadnagar, Mehsana, Gujarat, India. She has finished her Bachelor of Medicine and Bachelor of Surgery (MBBS) in 2004 and Pediatric Residency
in 2009. She has worked in Special Newborn Care Unit (SNCU) funded by UNICEF - Level 2 Neonatal Care Unit, District Hospital, Shivpuri from July 2009-Jan
2011 and General Hospital, Visnagar, Gujarat from Mar 2011-Nov 2014. She is certified in facility based newborn care under National Neonatology Forum (NNF)
and Pediatric Advanced Life Support. She has attended a workshop on Neonatal Ventilator in Ahmedabad, India. She has research interest in infectious diseases
in children especially HIV, tuberculosis, malaria and hepatitis B, neonatal critical care, childhood obesity and neonatal resuscitation. She has been involved in
newborn care training to auxiliary midwives, skilled birth attendant training and various CMEs.
drpragyakhanna@gmail.com