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Volume 5, Issue 2 (Suppl) J Infect Dis Ther 2017
ISSN: 2332-0877, JIDT an open access journal Infection Congress 2017
May 11-12, 2017
May 11-12, 2017 Barcelona, Spain
4th International Congress on
Infectious Diseases
Shakif Mohammad Shakur et al., J Infect Dis Ther 2017, 5:2 (Suppl)
The need for surveillance–A snapshot of antimicrobial resistance of gram-negative isolates in Australian
children with culture-proven bloodstream infections
Shakif Mohammad Shakur, John Whitehall and Poonam Mudgil
Western Sydney University, Australia
Gram-negative bloodstream infections cause significant morbidity and mortality of children worldwide. Rising rates of bacterial
resistance emphasizes the need for monitoring of causative organisms and their susceptibility patterns, to guide appropriate
antibiotic therapy. Antimicrobial resistance is an important public health issue and thus, monitoring of local populations is warranted.
We investigated cases of proven bacteraemia from infected children from a socio-economically disadvantage population. We
retrospectively reviewed the cohort of children aged 0 to 16 years who were admitted to a metropolitan hospital in Sydney, Australia,
from January 1, 2010 to August 31, 2014 inclusive, and whose blood cultures isolated gram-negative organisms. Data was collected
regarding patient demographics, species of bacteria isolated, antimicrobial susceptibility of these isolates, and clinical outcomes.
We identified a total of 35 isolates from 33 patients, of whom 45% were aged <12 months. The most common gram-negative isolate
was Escherichia coli (42%), followed by Salmonella spp. (12%) and Neisseria meningitidis (12%). The most common primary site of
infection was the urinary tract, accounting for 33% of patients. Escherichia coli showed high rates of resistance to ampicillin (43%),
trimethoprim (36%) and co-trimoxazole (41%). The majority of Escherichia coli isolates were susceptible to amoxicillin/clavulanate
(81%) and all isolates tested against ceftriaxone and gentamicin was susceptible. Most other isolates showed >90% susceptibility to
common antimicrobial agents. In this single-centre study, we have drawn attention to a high rate of resistance of Escherichia coli
bacteria to common antimicrobial agents. This highlights the importance of ongoing surveillance of local populations, and may
warrant changes to empirical antibiotic treatment in the near future.
Biography
Shakif Mohammad Shakur has completed his Bachelor of Medicine/Bachelor of Surgery at Western Sydney University, Australia. Currently, he is a Junior Medical
Officer at Campbelltown Hospital, a 300 bed hospital located at South Western Sydney, New South Wales, Australia.