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Volume 5, Issue 2 (Suppl) J Infect Dis Ther 2017
ISSN: 2332-0877, JIDT an open access journal Infection Congress 2017
May 11-12, 2017
May 11-12, 2017 Barcelona, Spain
4th International Congress on
Infectious Diseases
Linda Bridina et al., J Infect Dis Ther 2017, 5:2 (Suppl)
Biochemical and microbiological profile of patients admitted with sepsis in an intensive care unit
Linda Bridina and Angelika Krumina
Riga Stradins University, Latvia
Background: Beyond issues related to measurement, the incidence of sepsis depends on host, pathogen and system factors, for
example, lifestyle, sex, race, immune response, chronic health disorders, distribution of pathogens, and access to intensive care.
Although these factors are articulated as separate entities, their complex interplay is crucial to consider.
Materials & Methods: The retrospective analysis of 72 patients’ medical records was carried out. The research included both sexes
and all ages’ patients who were hospitalized at Riga Eastern Clinical University Hospital inpatient "Gaiļezers" from 2011 to 2014 years.
Blood test on the sterility and identification of blood culture were performed for all the patients. Data was described using means
with standard deviations (SD), median with interquartile range (IQR), Mann-Whitney U method, chi-square tests. Data statistical
analysis was done in SPSS.
Results: From all 72 (100%) patients included in the study, 67 (93.05%) patients had immuno compromised background- tumors,
intra-abdominal infections, complicated soft tissue infections, cardiovascular, endocrine, lung, liver, kidney diseases, HIV, viral
hepatitis and alcohol addiction. Five (6.9%) patients were not diagnosed with related diseases. Our data showed that most of the
patients were in the age group of 60 to 79 (n=32.44%) and 20 of them (62.5%) died. Summarizing the results, all patients at the
time of hospitalization had elevated C reactive protein (CRP). More than the half of patients 56 (77.7%) CRP was above 259 mg/L.
Leukocytosis was diagnosed with 59 (81.9%) patients. Leukopenia was diagnosed with six (8.3%) patients. 32 (44.4%) patients had
elevated liver indicators (ALT, AST). 39 (54.1%) patients had elevated kidney indicators. But the renal replacement therapy during
hospitalization was received by 13 (18.1%) of patients. For the dead patients (n=36.50%) the renal replacement therapy was received
by 25% (p = 0.12). Plating of blood was positive in 32 (44.4%) of all the patients. Blood agent in culture grows-Streptococcus beta-
hemolytic group B was 1 (3.1%), Escherichia coli 3 (9.37%), Staphylococcus epidermidis 5 (15.6%), Staphylococcus hominis 1 (3.1%),
Staphylococcus aureus 7 (21.9%), Staphylococcus haemolyticus 1 (3.1%), Prevotella oralis 1 (3.1%), Streptococcus pneumonia10 (31.3%),
Klebsiella pneumonia 1 (3.1%), Clostridium difficile 1 (3.1%), Streptococcus beta-hemolytic group A 1 (3.1%). Microbiological plating
of urine was positive in 11 (15.3%) patients; the most common agents in plating were E. coli and Staphylococci .
Conclusion: In our study, blood culture was mostly positive for less than a half of patients (44.4%). In most instances, bloodstream
infections are intermittent and the circulating microbial loads are low; it makes the diagnosis and treatment of sepsis even harder.
Biography
Linda Brīdiņa is currently studying at Riga Stradins University, Latvia. Her study mainly focuses on “Infection and immune system, biochemical and microbiological
research on patients with sepsis”.