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Volume 7
Journal of Traditional Medicine & Clinical Naturopathy
Herbal Traditional 2018
December10-11, 2018
Page 48
Notes:
December10-11, 2018 Dubai, UAE
International Conference on
Herbal & Traditional Medicine
Chemical composition and attenuates quorum sensing regulated virulence and biofilm formation of
avocado oil
Hanan M Al-Yousef
1
, Wafaa H B Hassan
2
, Musarat Amina, and Syed Rizwan Ahamad
3
1
Department of Pharmacognosy, College of Pharmacy, King Saud University, Saudi Arabia
2
Department of Pharmacognosy, College of Pharmacy, Zagazig University, Egypt
3
Central laboratory, Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Saudi Arabia
Background:
The aim of this study was to investigate the chemical components of avocado oil as well as to explore the effect of
this oil on QS and related virulence factors of P. aeruginosa. QS is a key regulator of virulence factors of P. aeruginosa such as
BF, motility, productions of proteases, hemolysin, and PPcyanin. The pathogenesis of bacteria might be owing to their ability to
sense and respond to population density. QSI system is considered as a new technique for the development of antipathogenic
agents, mainly for drug-resistant bacterial.
Method:
In this study, we are identified the chemical compositions from oil of avocado by using GC/MS, also, the anti-QS
activity of avocado oil was investigated against CVO26 and PAO1.
Result:
A total of 23 compounds representing 98.67% by using GC/MS. Avocado oil inhibits the QS-mediated virulence factors
production such as violacein in CVO26 and elastase, PPcyanin in PAO1. In addition to, the using of sub-MICs of avocado oil
significantly inhibited the QS-mediated BF, EPS production and swarming motility.
Conclusion:
This study illustrated, for the first time, the importance of avocado oil composition asQSI and virulence suppressors
of PAO1 and as a potent antioxidant. Thus, this oil could provide a natural source for the inhibition of Pseudomonas toxins.
Biography
Hanan M Al-Yousef have worked in MOH in the field of Narcotic and Psychiatric Drugs. Also, in the field of licences for medicine and pharmacy. He worked in
Pharmacy College, KSU, Riyadh, as associate professor in Pharmacognosy. He also was participated in teaching of the courses at different levels (under and post-
graduate students). In addition, He worked as Vice dean of Al-Ghad international health sciences (a private college) and he Certified a coach for the dissemination
of the culture of dialog from centre of national dialog. He has many activities as participate in university celebrations. Participating in the arbitration of research
proposals, day of scientific research, unified program of admission to health colleges and he attended many workshops and courses inside and outside the
university, in addition to, my involvement in many committees. Also, as volunteer to serve the community. He has written two books.
halyousef@ksu.edu.saHanan M Al-Yousef
et al., J Tradit Med Clin Natur 2018, Volume 7
DOI: 10.4172/2573-4555-C4-012