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Volume 7
Journal of Traditional Medicine & Clinical Naturopathy
Herbal Traditional 2018
December10-11, 2018
Page 47
Notes:
December10-11, 2018 Dubai, UAE
International Conference on
Herbal & Traditional Medicine
In vitro
antioxidant and iron chelating effects of ficuspalmata extracts on thalassemia patients sample
Dunya Ahmed Nori
1
, Elbaroudi G H
1
, Choudhry H
1
, Filimban F
1
, Elassouli M Z
2
and Helmi N
3
1
University of Jeddah, Saudi Arabia
2
King Fahad Mediacl Research Center, Saudi Arabia
3
University of Jeddah, Saudi Arabia
Background:
Thalassemia is a family of hereditary disorders characterized by impaired erythropoiesis and decreased rate
of globin production[1]. It can be clinically classified into three forms: transfusion-dependent thalassemia major (TM),
asymptomatic thalassemia trait (minor), and thalassemia intermedia
[2,3]
. Individuals with TM need regular blood transfusions,
which result in iron accumulation and oxidative cell damage to tissues
[4,5]
. Many natural plants have been used for the
development of new pharmaceutical drugs for the treatment of various diseases such as iron chelators and antioxidants for
treatment of iron overload[6]. The aim of this study was to evaluate antioxidant and iron chelating effects of extracted of
FicusPalmata(FP) plant that been harvested from mountain in Saudi Arabia on Thalassemia Patients.
Method:
The active component of the FP was extracted with two solvents: water(W) and methanol(M). For measuring the
antiradical activities of the extract, the scavenging result of the stable 2,2-diphenyl-1-picrylhydrazyl(DPPH) method was
used[7]. To evaluate the iron chelator effect, 5ml of blood sample was collected from 20 thalassemic patients with iron overload.
The FP extract was added at 5mg/ml final concentration on each sample then the iron levels were measured.
Result:
The decolorization percentages of methanolic and water extracts of the FP were as follows, 96.1% M and 82.7% W
compared to 96% of vitamin E as a control. Furthermore, all the treated sample showed significantly decreased (P-value =0000)
in iron levels with extracted plant relatively to untreated samples.
Conclusion:
Based on our results, the FP plant can be considered a good source for the antioxidants and can be used as iron
chelation therapy especially with patients whom have iron overload. Thereby, it is recommended to establish further studies
on specific compounds of antioxidants in order to give complementary study of the drug formulas and the toxic effect on the
body tissues.
Biography
Dunya Ahmed Nori completed his Master degree in Science at the age of 29 years from king Abdu Alaziz university in 2017 with excellent degree in Biochemistry
field. She got the Bachelor degree from the same university in the same field in 2013 with excellent degree - first honors. She has published two papers in reputed journals.
dany667@hotmail.comDunya Ahmed Nori
et al., J Tradit Med Clin Natur 2018, Volume 7
DOI: 10.4172/2573-4555-C4-012