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conferenceseries
.com
Volume 8, Issue 10 (Suppl)
J Diabetes Metab
ISSN: 2155-6156 JDM, an open access journal
Herbal Diabetes 2017
November 02-04, 2017
November 02-04, 2017 Bangkok, Thailand
23
rd
International Conference on
Herbal and Alternative Remedies for
Diabetes and Endocrine Disorders
Comparative effectiveness of
Abelmoschus esculentus
L. (Okra) and acarbose in lowering blood
glucose: An experimental study using streptozotocin-induced diabetic rats
Anniline C Teng, E D V Marcelo, S A Mohamed, S A C Ong Siu, A L P Orille, R P D Punzalan, P S V Sawen, A C Teng, F M C De Guzman and D P Wy
Manila Central University, Philippines
D
iabetes is presently a serious worldwide epidemic, affecting about 382 million people globally in 2013 and directly causing
the deaths of more than 1.5 million people in 2012. This study evaluates the glucose-lowering potential of
Abelmoschus
esculentus L.
(Okra) in diabetic rat models as compared to the commercial drug acarbose. In this randomized, double-blind
experimental study, 48 streptozotocin-induced diabetic male Sprague Dawley rats aged 75-90 days old and weighing 150-250
grams were divided into three groups: (1) Experimental group which was given 300 mg/kg aqueous extract of
Abelmoschus
esculentus L
. (okra), (2) Positive control group which was given 15 mg/kg acarbose and (3) Negative control group which was
given 5 mL/kg distilled water. All groups were concurrently treated once daily orally for 7 days. Blood glucose levels were
measured one hour after treatment administration using EasyTouch® glucometer. The safety of okra extract and acarbose were
also determined based on subject mortality. After 7 days, the experimental group and the positive control group demonstrated
glucose-lowering effects. However, the decrease in blood glucose from the baseline up to day 7 was statistically significant only
in the experimental group (p-value<0.05). Comparison of the glucose values among all the groups on day 7 demonstrated a
significant difference in the experimental group (p value=0.02). This showed that okra extract exhibited a time-dependent
effect. Also, statistical analysis of mortality which yielded a non-significant result established the safety of acarbose and okra
extract as used in the study.
These findings prove the potential beneficial effect of
Abelmoschus esculentus L.
(Okra) in the treatment of diabetes through its
glucose-lowering effect which has been exhibited to be comparable to that of the commercially prepared drug acarbose. Thus,
it may be developed and used to treat type-2 diabetes in humans.
Biography
Anniline C Teng is currently a Medical student, doing Internship in Manila Central University Hospital in EDSA, Caloocan City, Philippines.
anniline_teng@yahoo.comAnniline C Teng et al., J Diabetes Metab 2017, 8:10 (Suppl)
DOI: 10.4172/2155-6156-C1-072