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conferenceseries
.com
Volume 8, Issue 10 (Suppl)
J Diabetes Metab
ISSN: 2155-6156 JDM, an open access journal
Herbal Diabetes 2017
November 02-04, 2017
November 02-04, 2017 Bangkok, Thailand
23
rd
International Conference on
Herbal and Alternative Remedies for
Diabetes and Endocrine Disorders
Hypolipidemic activity of
Madhuca longifolia
in Triton-induced hyperlipidemic rats
Abhijit Shrirao, Kochar N I and Chandewar A V
P. Wadhwani College of Pharmacy, India
Objective:
In the present study, an ethanolic extract from
Madhuca longifolia
bark was evaluated for its hypocholesterolemia
and hypotriglyceridemic activities using Triton WR-1339 induced hyperlipemic rats as experimental model.
Material & Method:
Hyperlipidemia was induced by a single injection of Triton WR 1339 (400 mg/kg i.p.) in Sprague Dawley
rats. Ethanolic extract of
Madhuca longifolia
bark (ML) (250, 500 and 750 mg/kg/day) was administered to hyperlipidemic
rats for one week. Harvested serum was analyzed for lipid profile such as cholesterol, triglyceride and lipoproteins. Oxidative
stress parameters like Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GPx) and glutathione reductase
(GRh) and activity of lipolytic enzyme such as Lecithin-Cholesterol-Acyltransferase (LCAT) and Post-Heparin lipolytic
activity (PHLA) were estimated in the liver tissues of hyperlipidemic rats.
Results:
Result of the study suggested that treatment with ML 750 mg/kg/day significantly (p0.01) lowered the level of serum
cholesterol, triglyceride phospholipids and increased in lecithin-cholesterol-acyltransferase activity and post-heparin lipolytic
activity compared to Triton-treated rats. In addition, ML 750mg/kg/day significantly (p0.01) reduces oxidative stress and
normalizes the activities of SOD, CAT, GPx and GRh compared to Triton-treated rats.
Conclusion:
The current study provides strong evidence that intragastric administration of ML 750 mg/kg/day has a beneficial
effect in treating dyslipidemia with decrease in oxidative stress.
Biography
Abhijit Shrirao has completed his MPharmacy in Pharmacology from NMIMS University, Mumbai. He has an experience of 1.5 years in Clinical R&D and 6 years
of academic experience. Currently, he is working as an Assistant Professor at P. Wadhwani College of Pharmacy, Yavatmal, India. He has interest in developing
medicines from herbal origin which are cheap and having less adverse effects and is studying herbs for their possible antidiabetic and antihyperlipidemic activity.
abhishrirao@gmail.comAbhijit Shrirao et al., J Diabetes Metab 2017, 8:10 (Suppl)
DOI: 10.4172/2155-6156-C1-072