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conferenceseries
.com
Volume 8, Issue 10 (Suppl)
J Diabetes Metab
ISSN: 2155-6156 JDM, an open access journal
Herbal Diabetes 2017
November 02-04, 2017
November 02-04, 2017 Bangkok, Thailand
23
rd
International Conference on
Herbal and Alternative Remedies for
Diabetes and Endocrine Disorders
Beneficial effect of
Aloe vera
on renal functions in STZ-induced diabetic nephropathic animal by
reducing oxidative stress and electrolyte imbalance
Suraj T Landge, N I Kochar and A V Chandewar
Pataldhamal Wadhwani College of Pharmacy, India
D
iabetic nephropathy is the vascular complications of diabetes diagnosed by increase blood pressure, micro albuminuria
and decrease GFR. The present study evaluates the possible beneficial effects of
Aloe vera Power
(AP) on renal functions
in STZ induced Diabetic Nephropathic (DN) animal and its possible mechanism. Diabetic nephropathy was induced by single
dose of STZ (60 mg/kg of body weight, i.p.) and confirms it by assessing the blood and urine biochemical parameters on
28th day of after its induction. Selected DN animal were treated with AP (150 mg/kg and 300 mg/kg, p.o.) for the period of
four week. Biochemical parameters in blood and urine were estimated after four weeks of treatment i.e. 56th day of protocol
and oxidative stress parameters like Lipid Peroxidation (LPO), Superoxide Dismutase (SOD), Catalase (CAT) and reduced
Glutathione (GSH) were estimated in the tissue homogenate of kidney. It was observed that treatment with AP results in
significant improvement in renal function parameters. Results of the study also suggested that AP treated group’s shows
significant improvement in the oxidative stress parameters like decrease in SOD, CAT and GSH level and increase in LPO level
significantly (p<0.01) compared to DN animal. The levels of electrolytes were found to be improved in AP treated DN animal
compared to DN animal. Present study concluded that AP ameliorates the renal function by reducing the oxidative stress and
electrolyte imbalance in DN animals.
surajlandge@gmail.comJ Diabetes Metab 2017, 8:10 (Suppl)
DOI: 10.4172/2155-6156-C1-073