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conferenceseries
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Volume 8, Issue 10 (Suppl)
J Diabetes Metab
ISSN: 2155-6156 JDM, an open access journal
Herbal Diabetes 2017
November 02-04, 2017
November 02-04, 2017 Bangkok, Thailand
23
rd
International Conference on
Herbal and Alternative Remedies for
Diabetes and Endocrine Disorders
Insulin sensitizing effect of cinnamon
Geetendra Singh Dhanawat
Aditya Bharti Center for Diabetes, India
I
n our 14 month of clinical study, the commonly used Indian spice Cinnamon showed excellent results in pre-diabetic and
newly diagnosed diabetic patients. In our clinical study, we have tested the blood sugar lowering and insulin-sensitizing
effects of Cinnamon (
Cinnamomum cassia
). In our study, we have used 3 gm of cinnamon in capsules to people with diabetes
for 90 days. In 45 days, improvements in both fasting blood sugar and in LDL (bad) cholesterol evidenced. Although some
clinical trial results have been equivocal, several have shown benefits of cinnamon on glucose, lipid and insulin levels. Studies
also showed, cinnamon can potentiate insulin action and improve insulin resistance and glucose metabolism, although the
detailed biochemical mechanisms aren't completely clear. Bioactive compounds in cinnamon affect several steps in insulin
signaling pathways. For example, research has shown that certain water-soluble polyphenol compounds (type A polyphenols)
extracted from cinnamon may increase insulin sensitivity by inhibiting an enzyme (a tyrosine phosphatase) that inactivates
insulin receptors. Other research has found that water-soluble cinnamon polyphenols increase insulin-dependent proteins
(GLUT-4) required for glucose uptake by adipose and muscle cells. Cinnamon extracts also may decrease proteins involved in
glucose production in the liver (gluconeogenesis). In addition, cinnamon compounds have antioxidant and anti-inflammatory
actions, which may play a role in reducing insulin resistance and diabetes complications. The consumption of cinnamon is
associated with a statistically significant decrease in levels of fasting plasma glucose, total cholesterol, LDL-C and triglyceride
levels and an increase in HDL-C levels. However, no significant effect on hemoglobin A1c was found. The high degree of
heterogeneity may limit the ability to apply these results to patient care, because the preferred dose and duration of therapy
are unclear.
gskgeetendra@rediffmail.comJ Diabetes Metab 2017, 8:10 (Suppl)
DOI: 10.4172/2155-6156-C1-073