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conferenceseries
.com
Volume 8, Issue 10 (Suppl)
J Diabetes Metab
ISSN: 2155-6156 JDM, an open access journal
Herbal Diabetes 2017
November 02-04, 2017
November 02-04, 2017 Bangkok, Thailand
23
rd
International Conference on
Herbal and Alternative Remedies for
Diabetes and Endocrine Disorders
Beneficial effect of
Amorphophallus paeoniifolius
in the management of diabetic neuropathy
D S Mohale and A V Chandewar
P. Wadhwani College of Pharmacy, India
P
resent study was undertaken to evaluate the effect of tubers of
Amorphophallus paeoniifoliusin
the treatment of diabetic
neuropathy.
Amorphophallus paeoniifolius
(Araceae family) have been widely used as a potential natural medicinal product
in traditional Indian Ayurveda. Animals were divided in 4 groups (n=6), diabetes was induced by STZ 60 mg/kg, IP and treated
with methanolic extract of
Amorphophallus paeoniifolius
at of 250 mg/kg and 500 mg/kg p.o. dose for 3 weeks. Measurement
of blood glucose level was used to determine diabetes. For determination of diabetic neuropathy tail flick, swim endurance
test and Rota-road method were used. There was significant increase (p<0.01) in the blood glucose level in negative group
compared to control group of rats. There was decrease (p<0.01) blood glucose level in STZ+AP extract (250 mg/kg) and
STZ+AP extract (500 mg/kg) treated group compared to Negative-control Group. There was significant increase (p<0.01) in
time to flick the tail of diabetic rats compared to control group which were significantly improved in STZ+AP extract (250 mg/
kg) and STZ+AP extract (500 mg/kg) treated group compared to Negative-control group. Muscle strength was significantly
decreased (p<0.01) in rats treated with STZ analyzed on Rota-rod apparatus. There was significant improvement (p<0.01) in
muscle strength in STZ+AP extract (250 mg/kg) and STZ+AP extract (500 mg/kg) treated group compared to negative-control
group. Mobility time was decreased in negative group measured in force swim test and treatment with STZ+AP extract (250
mg/kg) and STZ+AP extract (500 mg/kg) shows significant improvement in mobility time treated group compared to negative-
control group. Present study concludes that methanolic extract of
Amorphophallus paeoniifolius
may be useful in treatment and
management of diabetic neuropathy.
deepak.mohale@gmail.comJ Diabetes Metab 2017, 8:10 (Suppl)
DOI: 10.4172/2155-6156-C1-073