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.com
Volume 7, Issue 5 (Suppl)
J Gastrointest Dig Syst, an open access journal
ISSN:2161-069X
Gastroenterology 2017
November 13-14, 2017
November 13-14, 2017 | Las Vegas, USA
13
th
International Conference on
Clinical Gastroenterology, Hepatology and Endoscopy
Epidemiological and clinical evaluation of Hepatitis B, Hepatitis C, and Delta H viruses in Tajikistan Hepatitis
Khakimova Zebinniso
Ministry of Health and Social Protection, Tajikistan
T
he implication of genotypes is recognized increasingly in the clinical course of
Hepatitis B virus
(HBV) and in response to anti-viral
drugs of
Hepatitis C virus
(HCV). Genotypic prevalence of both etiological agents varies geographically and no data are available
for Tajikistan. To investigate the epidemiology and clinical significance of HBV and HCV genotypes in chronic hepatitis (group 1)
and liver cirrhosis/hepatocellular carcinoma (HCC) (group2) patients in Tajikistan, 124 patients with chronic liver disease (group
1=84 and group 2=40) were enrolled. Genotypes of HBV, HCV, and delta hepatitis virus (HDV) were deter-mined by sequencing.
The overall prevalence of anti-HCV, HCV coreantigen (HCVcAg) and HBsAg was 46% (57/124) and 41.1% (51/124), respec¬tively.
Coinfection of HCV/HBV, HBV/HDV, and HCV/HBV/HDV was found in 4.8% (6/124), 11.2% (12/124), and 0.8% (1/124) of cases,
respectively. HDV genotype 1 was found in 19.6% (10/51) of HBsAg-positive patients. The HBV/HDV coinfection was relatively
high in group 2 compared to group 1 (15% vs. 7.1%). HCV/1b detected in 84.6% (44/52) of HCVRNA-positive patients, followed by
3a (7.6%), 2a (5.7%), and 2c (1.9%). HBV/D was detected in 94.1% (48/51) of HBsAg-positive patients, followed by HBV/A [5.8%
(3/51)]. T1762/A1764 double mutation was associated with livercirrhosis/HCC in HBV-infected patients (P=0.0004). This is the first
study on the mole¬cular epidemiology of Hepatitis viruses among chronic liver diseases patients in Tajikistan. Among HBV-infected
patients, the T1762/A1764 mutation was associated with liver cirrhosis/HCC.
Biography
Khakimova Zebinniso at the age of 37 years graduated from Instutute of Gastroenterology of the Republic of Tajikistan. She works at the Department of Virology, Institute
of Gastroenterology of the Republic of Tajikistan. She has published more than 5 papers in reputed journals.
dustovsamad@gmail.comKhakimova Zebinniso, J Gastrointest Dig Syst 2017, 7:5 (Suppl)
DOI: 10.4172/2161-069X-C1-056