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Volume 7, Issue 5 (Suppl)
J Gastrointest Dig Syst, an open access journal
ISSN:2161-069X
Gastroenterology 2017
November 13-14, 2017
November 13-14, 2017 | Las Vegas, USA
13
th
International Conference on
Clinical Gastroenterology, Hepatology and Endoscopy
Associations betweenmetabolic syndrome and liver stiffnessmeasured bymagnetic resonance elastography
in NAFLD patients
Hyo Sun Lee, Ho Jung Jung, Heon-Ju Kwon, Mi Yeon Lee
and
Yong Kyun Cho
Sungkyunkwan University, South Korea
Background:
Metabolic syndrome (MS) and its components are associated with the development and the progression of nonalcoholic
fatty liver disease (NAFLD). NAFLD includes a spectrum of liver damage ranging from simple steatosis to nonalcoholic steatohepatitis
and advanced fibrosis. In this study, we aimed to evaluate the relationship between liver stiffness measured by magnetic resonance
elastography (MRE) and MS components in patients with NAFLD.
Methods:
A total 650 middle-aged nondiabetic NAFLD subjects with and without MS [male, n=540 (83.1%); female, n=110 subjects
(16.9%); median age, 52 years; range, 31-79] quantified the liver stiffness by using MRE with a 3.0-T MR system. Based on the
previous studies, we defined the cutoff value for liver stiffness as 2.87 kPa to differentiate between healthy and fibrous liver. We also
examined how liver stiffness is related to individual component of the MS using multivariate logistic regression analysis.
Results:
After adjustment for gender and age, liver stiffness was 2-fold higher in subjects with MS than in those without (aOR=2.11;
95%CI, 1.07-4.15). Liver stiffness was correlated significantly with number of MS components usingWHO clinical criteria (aOR=1.35;
95%CI, 1.04-1.74), homeostatic model assessment of insulin resistance (aOR = 1.39; 95%CI, 1.18-1.62), body mass index (aOR=1.14;
95% CI, 1.02-1.26), and waist circumference (aOR=1.05; 95% CI, 1.01-1.10). Among MS components, the best correlation of liver
stiffness was presence of hypertension. (aOR=2.16; 95% CI, 1.11-4.18).
Conclusions:
The liver stiffness was significantly higher inmiddle-aged nondiabetic NAFLD patients withMS. High insulin resistance
and the presence of hypertension were major determinants of increased liver stiffness in NAFLD.
Biography
Hyo Sun Lee is graduated from Chonbuk National Univercity Medical School and completed intern and residency courses at Kangbuk Samsung Hospital . She is currently
working as a fellow in gastroenterology and hepatology department at Kangbuk Samsung Hospital.
hsl0206@naver.comHyo Sun Lee et al., J Gastrointest Dig Syst 2017, 7:5 (Suppl)
DOI: 10.4172/2161-069X-C1-056