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conferenceseries
.com
Volume 7, Issue 7 (Suppl)
J Gastrointest Dig Syst
ISSN: 2161-069X JGDS, an open access journal
Gastroenterologists 2017
December 14-15, 2017
December 14-15, 2017 Dubai, UAE
11
th
World
Gastroenterologists Summit
Evaluation of
Helicobacter pylori
as a predicting risk factor for the development of IGR in pre-
eclamptic patients
Zeinab Nabil Said, Moneira Gad, Amal Abdelnaby, Azza Ghanem and Marwa Tantawy
Al-Azhar University, Egypt
P
re-eclampsia (PE) is a major cause of maternal and neonatal mortality and morbidity. There is mounting evidence that
certain infectious agents including Helicobacter pylori can induce endothelial inflammation and injury. The aim of this
work is to evaluate the pathogenic role of Helicobacter pylori in PE and whether it is associated or not with intrauterine
growth retardation (IUGR). Maternal sera were collected from 45 pregnant women with a diagnosis of PE and/or IUGR and
from 45 women with normal pregnancies of comparable age and gestational period (controls) for detection of antibodies
against H. pylori and specific antibodies against CagA protein using commercially available ELISA kits. Seropositivity was
determined according to manufacturer’s instructions. No significant difference was detected between patients and controls
regarding H. pylori IgG antibody seropositivity and CagA positivity (P> 0.05). Patients with early onset PE had significantly
higher frequency of H. pylori IgG. No significant association was found between CagA and PE onset (P< 0.05). A significantly
higher frequency of IUGR was recorded in HP positive patients (12 (33.3%) when compared with HP negative ones (0%) (P<
0.05). It was found that all patients with PE and IUGR (12) had significantly higher frequency of both H. pylori and CagA
positivity when compared with PE patients without IUGR and control groups. (P< 0.05). H. pylori infection is quite prevalent
in Egyptian community. Virulent H. pylori infections may be a risk factor to PE complicated by IUGR.
znabil58@yahoo.comJ Gastrointest Dig Syst 2017, 7:7 (Suppl)
DOI: 10.4172/2161-069X-C1-062