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conferenceseries
.com
Volume 7, Issue 7 (Suppl)
J Gastrointest Dig Syst
ISSN: 2161-069X JGDS, an open access journal
Gastroenterologists 2017
December 14-15, 2017
December 14-15, 2017 Dubai, UAE
11
th
World
Gastroenterologists Summit
Metabolomics as novel non-invasive diagnostic biomarkers of GI disorders
Iftikhar Ahmed
University Hospital Southampton NHS Foundation Trust, UK
D
iagnosis of gastrointestinal disorders requires extensive and often invasive investigations including endoscopy a biopsies
and places a heavy burden, both on healthcare resources, because of the cost and on the individual, in times of disease-
related disability and poor quality of life. Recently, there has been increasing interest in non-invasive biomarkers to diagnose
various gastrointestinal and liver disorders. There is growing scientific interest in the investigation of metabolomics and
numbers of studies have focused on the utilization of non-invasive biomarkers in the diagnosis of GI disorder in particular
inflammatory bowel disease. The development of sophisticated analytical techniques has enabled the study and interpretation
of changes in the fecal and breath volatile organic metabolites (VOMs) and its correlation with the pathophysiological
mechanisms in the gut. VOMs are the chemicals that are the products and intermediates of metabolism and may be altered in
liver diseases. Changes in fecal VOMs should reflect GI disorders and could potentially provide diagnostic information about
these conditions. Multiple studies reported the differences in VOM profiles of healthy controls vs. patients with liver and other
GI disorders. VOM profiles have been used to segregate patients by disease activity and the type of disease. The correlation of
VOMs with microbiota is interesting and supports the hypothesis of gut microbial dysbiosis in the etiology of GI disease. This
provides an important platform to explore the role of dysbiosis in gut and other GI disease pathogenesis and development of
novel therapeutic targets. In future, further understanding of fecal VOMs may lead to the development of a rapid and simple
point of care diagnosis and monitoring of GI disorder.
iftikhar.ahmed5@nhs.netJ Gastrointest Dig Syst 2017, 7:7 (Suppl)
DOI: 10.4172/2161-069X-C1-062