gastro-congress-2016_posters-accepted-abstracts

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Volume 6, Issue 7(Suppl) J Gastrointest Dig Syst 2016
ISSN: 2161-069X JGDS, an open access journal
Page 71
Gastro Congress 2016
October 24-25, 2016
conferenceseries.com
October 24-25, 2016 Valencia, Spain
9th Euro Global
Gastroenterology Conference
J Gastrointest Dig Syst 2016, 6:7(Suppl)
Adiponectin, Leptin, IGF1 and TNFα serum biomarkers for non-invasive diagnosis of colorectal
adenoma
1Hassan Ashktorab, 1Akbar Soleimani, Hasti Olumi, 3Alexandra Nichols, 3Komal Sodhi, Laiyemo O Adeyinka, 1Mehdi Nouraie, 2Hassan Brim
1Department of Medicine and Cancer Center, 2Department of Pathology, Howard University College of Medicine, Washington DC
3Department of Surgery and Pharmacology and Translational Research Marshall University Joan Edwards School of Medicine, WV
Background and Aim: The potential role of Adiponectin, Leptin, IGF1 and TNFα as biomarkers in colorectal adenoma is not
clear. Therefore, we aimed to investigate the blood serum levels of these biomarkers in colorectal adenoma.
Method: The case-control study consisted of serum from 180 African American patients with colon adenoma (cases) and 198
healthy individuals (controls) at Howard University Hospital. We used ELISA for Adiponectin, Leptin, IGF1 and TNFα detec-
tion and quantification. Statistical analysis was performed by t-test and multivariate logistic regression.
Results: The respective differences in median Leptin, Adiponectin, IGF1 and TNFα levels between control and case groups
(13.9 vs. 16.4), (11.3 vs. 46.0), (4.5 vs. 12.9) and (71.4 vs. 130.8) were statistically significant (p<0.05). In a multivariate model,
the odds ratio (ORs) for Adiponectin, TNFα and IGF1 were 2.0 (95% CI=1.6–2.5; P<0.001), 1.5 (95% CI=1.5– 2.0; P 0.004)
and 1.6 (95% CI=1.3–2.0; P< 0.001), respectively. There was a positive correlation between serum Adiponectin and IGF1 con-
centrations with age (r=0.17, P< 0.001 and r=0.13, P=0.009), TNFα, IGF1 and Leptin concentration with Body Mass Index
(BMI) (r=0.44, P< 0.001; r=0.11, P=0.03 and r = 0.48, P<0.001), respectively. Also, there was a negative correlation between
Adiponectin and Leptin concentration with BMI (r=-0.40, P<0.001 and), respectively.
Conclusion: These data support the hypothesis that Adiponectin, IGF1 and TNFα high level are increasing the risk of colon
adenoma and can be applied for colorectal adenomas risk assessment.
Evaluation of the impact of pre and post-transplant metabolic derangements on the neurological
complications following liver transplantation
Mohamed Mohamed Bassam Faek Mohamed Hashem
Kasr Al Ainy School of Medicine - Cairo University, Egypt
Neurologic complications after liver transplantation are a major source of morbidity and mortality and proper prediction
for those at risk may help in improving the outcome. The results of our study showed that severity of end stage liver
failure prior to transplantation might be the most common risk factor for the development of post-transplant neurological
complications and careful evaluation of other risk factors may be required for those patients in order to decrease the
incidence of complications. Still the use of tacrolimus is associated with risk of neurological complications and reduction or
discontinuation of tacrolimus lead to improvement of neurological complications. According to our study, electrolytes and
metabolic derangements are not risk factors for development of neurological complications. Although, the risk of neurological
complications in our series is high but there was no impact on the survival.