gastro-congress-2016_posters-accepted-abstracts

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Volume 6, Issue 7(Suppl) J Gastrointest Dig Syst 2016
ISSN: 2161-069X JGDS, an open access journal
Page 67
Gastro Congress 2016
October 24-25, 2016
conferenceseries.com
October 24-25, 2016 Valencia, Spain
9th Euro Global
Gastroenterology Conference
J Gastrointest Dig Syst 2016, 6:7(Suppl)
Aurora kinase A is a prognostic marker in colorectal cancer patients
Hyun Min Koh
Jeju National University, South Korea
Background & Aim: Aurora kinase A is a member of the serine/threonine kinase family and plays important roles in mitosis
and chromosome stability. This study aimed to evaluate the clinical significance of Aurora kinase A expression in colorectal
cancer patients in Korea.
Methods: Aurora kinase A protein expression was evaluated by immunohistochemistry in 151 patients with colorectal
adenocarcinoma using tissue microarray blocks. We then analyzed the relationship between clinicopathological characteristics
and Aurora kinase A expression. In addition, we assessed the prognostic significance of various clinicopathological data for
progression-free survival.
Results: Aurora kinase A expression was detected in 45% (68/151) of the cases. Positive staining for Aurora kinase A was
observed more often in male patients (P=0.035) and distally located tumors (P=0.021) progression-free survival was shorter in
patients with Aurora kinase A expression compared to those with low-level Aurora kinase A expression (P<0.001). Univariate
analysis revealed that Aurora kinase A expression (P=0.001), age (P=0.034), lymphatic invasion (P=0.001), perineural invasion
(P=0.002), and TNM stage (P=0.013) significantly affected progression-free survival. In a multivariate analysis of progression-
free survival, a Cox proportional hazard model confirmed that Aurora kinase A expression was an independent and significant
prognostic factor in colorectal adenocarcinoma (hazard ratio, 3.944; P<0.001).
Conclusions: Thus, Aurora kinase A could serve as an independent factor to predict a poor prognosis in Korean colorectal
cancer patients.
Endoscopic and morphological features of gastroduodenal pathology in adolescents with
connective tissue disorders
Yakovleva Inna
Institute of Children and Adolescents Health Care - National Academy of Medical Sciences of Ukraine, Ukraine
The aim of the present study is improving prophylaxis and treatment of chronic gastroduodenal pathology in adolescents on
the basis of determining clinical, endoscopic, and morphological peculiarities of said pathology. A total of 155 adolescents
11 to 18 years of age with inflammatory-destructive diseases of the upper gastrointestinal tract and Connective Tissue
Disorders (CTD) were studied. The traits of the CTD, including the Marfan syndrom, were determined relying on the Ghent
criteria. Morphological peculiarities are represented by high frequency of reflux-gastritis (77%) and a reduction in the level of
interstitial collagens type 3 and type 1 in the lamina propria of gastric and duodenal mucosa. The form of mucosal lesions is a
chronic non-atrophic (surface) gastritis with simultaneous inflammation in the antral and fundal parts. Duodenal ulcer was
detected in 12% only and it was accompanied by detection of Helicobacter pylori. The connective tissue matrix of the mucosa is
characterized by structural transformation of collagen fibrils (wrong orientation, focal sclerosis, immaturity). It is accompanied
by decrease in a mucosa functional ability with development of the valve-sphincter failure. The role of CTD in the development
of gastroduodenal pathology in puberty has been established. A genetically dependent insufficiency of interstitial collagens
is a major cause of development bile reflux, which is a leading factor of gastroduodenal pathology formation in adolescents
with CTD. The work provides grounds for employing in adolescents with CTD rehabilitation measures, connected with a
prevention of reflux-gastritis progression and stimulation of the collagen synthesis.