euro-toxicology-2016_scientifictracks-abstracts

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Volume 6, Issue 6(Suppl) J Clin Toxicol 2016
ISSN: 2161-0495, JCT an open access journal
Page 128
Notes:
Euro Toxicology 2016
October 24-26, 2016
conferenceseries.com
Toxicology & Applied Pharmacology
October 24-26, 2016 Rome, Italy
7th Euro-Global Summit on
The effect of the first- and second-generation of antipsychotic drugs on SH-SY5Y brain cells and
their toxicity
Israa J Hakeem
University of Birmingham, Edgbaston, UK
Antipsychotic drugs are primarily used to manage several psychiatric disorders, including schizophrenia, bipolar mania and
related mental illnesses. The present study examined the effect of the first and second generation of antipsychotic drugs
on neuronal and non-neuronal cells. The toxicity of both-generation of antipsychotics was tested in both the SH-SY5Y brain
cell line and the COS7 kidney cell line. According to the LC50 values for chlorpromazine (1st generation), Trifluoperazine
(1st generation) and Olanzapine (2nd generation), the neurotoxicity of the two classes in SH-SY5Y exceeded their common
cytotoxicity in COS7 cells, indicating that neuronal cells are at greater risk of cell death with low concentrations of antipsychotics
at micro-molar comparing to non-neuronal cells. Detailed studies looking at the mechanisms of cell death induced by these
antipsychotic drugs indicate that both apoptosis and necrosis play a role, while autophagy does not.
Biography
Israa J Hakeem is a PhD student at the University of Birmingham. She has completed her Master’s degree in Forensic Science from Anglia Ruskin University and
received Bachelor’s degree in Biochemistry.
Israa J Hakeem, J Clin Toxicol 2016, 6:6(Suppl)